{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:18:13Z","timestamp":1774048693396,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Human parechovirus (HPeV) is an increasingly recognised cause of severe illness and central nervous system infection in infants. Medium\u2010 to long\u2010term neurodevelopmental outcomes post\u2010HPeV infection remain unknown. This study aims to assess neurodevelopmental outcomes for children hospitalised as infants with HPeV infection in their second and third years of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study followed children hospitalised with HPeV in Brisbane, Queensland during the 2017\/2018 outbreak. Serial application of Ages and Stages Questionnaire (ASQ) was used to assess developmental progress in the second and third years of life. Data from clinical follow\u2010up, audiology and neuroradiology were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the second year of life, 63% (<jats:italic>n<\/jats:italic>\u00a0=\u200929) of children showed some or significant concerns for developmental delay. This had largely been ameliorated by the third year of life when only 30% (<jats:italic>n<\/jats:italic>\u00a0=\u200914) reported developmental concerns. Prematurity and apnoeas were associated with developmental concerns at 27\u201336\u2009months of age. Communication was the most common domain of concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of infants hospitalised with HPeV infection in 2017\u20132018 showed normalisation of developmental progress by 27\u201336\u2009months of age. Further investigation into more subtle neurological impairments in later childhood is required. These results can help guide clinicians in counselling parents during the acute illness and in planning appropriate follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15859","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T14:18:17Z","timestamp":1640873897000},"page":"856-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Parechovirus infection in infants: Evidence\u2010based parental counselling for paediatricians"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7265-1406","authenticated-orcid":false,"given":"Robyn A","family":"Silcock","sequence":"first","affiliation":[{"name":"Infectious Diseases Queensland Children\u2019s Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-7076","authenticated-orcid":false,"given":"Rebecca","family":"Doyle","sequence":"additional","affiliation":[{"name":"Queensland Health Centre of Children\u2019s Health Research  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia E","family":"Clark","sequence":"additional","affiliation":[{"name":"Infectious Diseases Queensland Children\u2019s Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Anne","family":"Kynaston","sequence":"additional","affiliation":[{"name":"General Paediatrics Queensland Children\u2019s Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Thomas","sequence":"additional","affiliation":[{"name":"General Paediatrics Queensland Children\u2019s Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meryta L","family":"May","sequence":"additional","affiliation":[{"name":"Microbiology Sullivan and Nicolaides Pathology  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja18.00149"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30288-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30180-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-2848"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002136"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21445"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2981-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30181-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.12.026"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.04.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05151-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.13728"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002988"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049732314562891"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2019.03.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002052"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002245"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-012-9210-5"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1131"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00261"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2006.09.010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315643"},{"key":"e_1_2_6_24_1","first-page":"1061","article-title":"Increased detection of human parechovirus infection in infants in England during 2016: Epidemiology and clinical characteristics","volume":"103","author":"Ferreras Antol\u00edn L","year":"2018","journal-title":"Arch. 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