{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:52:32Z","timestamp":1778100752900,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association of benign acute childhood myositis (BACM) with respiratory viruses. Also, we aimed to assess the effect of antiviral treatment on the improvement and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted at an urban\u2010academic emergency department during four influenza\u2010seasons (2016\u20132019), retrospectively. Demographics, clinical findings, laboratories, metabolic disease analyses and serological features were extracted from the medical records. Treatments, complications and outcomes were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 114 children were included. The median age was 7.0 (min 1.25\u2013max 17) years and 78.9% were male. The most common symptoms were leg pain (91.2%), anorexia (54.4%), fever (45.6%), sore throat (42.1%) and walking difficulty (32.5%). On admission, the median creatine phosphokinase level was 3332\u2009IU\/L (range, 1634\u201350\u2009185), median aspartate aminotransferase 107\u2009U\/L (range, 38\u20131798). In the multiplex polymerase chain reaction analysis, 40.4% <jats:italic>influenza B<\/jats:italic>, 36.8% <jats:italic>influenza A<\/jats:italic>, 7.8% <jats:italic>adenovirus<\/jats:italic>, 7.8% <jats:italic>parainfluenza<\/jats:italic> virus, 5.3% <jats:italic>rhinovirus<\/jats:italic>, 5.3% <jats:italic>respiratory syncytial virus<\/jats:italic> and 1.8% <jats:italic>Mycoplasma pneumoniae<\/jats:italic> were detected. Rhabdomyolysis was developed in 6.7% and acute renal failure was seen in two patients. Oseltamivir was given in 44 (38.6%) patients who had <jats:italic>influenza A\/B<\/jats:italic>. Metabolic disease screening tests were performed in 33.3% of patients and metabolic diseases were detected in 4 (3.5%) patients. The median recovery time was lower in patients with oseltamivir treatment (4 (min 2\u2013max 5)\u2009\u2212\u20095 (min 3\u2013max 10) days) (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rhabdomyolysis is more common in BACM due to the influenza A virus. The early use of oseltamivir treatment was significantly associated with a shorter recovery time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15894","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T10:54:53Z","timestamp":1644231293000},"page":"1022-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Benign acute childhood myositis associated with influenza A\/B in the paediatric emergency department and the efficacy of <scp>early\u2010onset<\/scp> oseltamivir"],"prefix":"10.1111","volume":"58","author":[{"given":"Caner","family":"Turan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Emergency Medicine Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-0204","authenticated-orcid":false,"given":"Ali","family":"Yurtseven","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Emergency Medicine Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candan","family":"Cicek","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulsum","family":"Keskin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eylem Ulas","family":"Saz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Emergency Medicine Ege University School of Medicine  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2017_79"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/tpa.630"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000830"},{"key":"e_1_2_7_5_1","first-page":"95","article-title":"Clinical features of influenza a and B in children and association with myositis","volume":"37","author":"Hu JJ","year":"2004","journal-title":"J. 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