{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T11:26:10Z","timestamp":1763810770762,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Congenital cytomegalovirus (cCMV) is the most common infectious cause of congenital malformation, non\u2010genetic sensorineural hearing loss and neurodevelopmental sequelae in childhood. The primary aim of this retrospective cohort study was to identify the birth and neurodevelopmental outcomes of neonates diagnosed with symptomatic and asymptomatic cCMV in a large regional tertiary referral hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of laboratory\u2010based cCMV diagnoses in neonates born at a single study centre between January 2005 and January 2020. Audit of medical records was undertaken to evaluate maternal characteristics, symptom patterns, radiological and neurodevelopmental outcomes of neonates meeting the laboratory diagnostic criteria during the first 24\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 45 neonates with proven CMV infection and 27 mothers with proven infection with an associated pregnancy outcome. Nineteen neonates were born at term (&gt;37\u2009weeks). Of these, 32 (71.1%) neonates had a significant intercurrent comorbidity and 22 (48.9%) neonates were reported to have a degree of delay in one or more developmental domains. A large proportion (77.3%) of the symptomatic untreated neonates had an unknown history of maternal infection compared to the asymptomatic (10.0%) and symptomatic treated (53.8%) neonates (<jats:italic>P<\/jats:italic>\u00a0=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Up to half of the neonates with cCMV were at risk of developing a degree of developmental delay at our centre. Whether these outcomes are related primarily to CMV infection or are confounded by the co\u2010existence of prematurity is unclear and needs further evaluation in prospective studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15914","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T12:05:01Z","timestamp":1646049901000},"page":"1136-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytomegalovirus infection in a single\u2010centre Australian neonatal cohort"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7905-9827","authenticated-orcid":false,"given":"Maheesha","family":"Seneviratne","sequence":"first","affiliation":[{"name":"Department of Paediatrics The Townsville University Hospital  Townsville Queensland Australia"},{"name":"College of Medicine and Dentistry James Cook University  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-893X","authenticated-orcid":false,"given":"Malindu E","family":"Fernando","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-8398","authenticated-orcid":false,"given":"Yogavijayan","family":"Kandasamy","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Townsville University Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"White","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Townsville University Hospital  Townsville Queensland Australia"},{"name":"College of Medicine and Dentistry James Cook University  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanaja","family":"Sabesan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Townsville University Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Norton","sequence":"additional","affiliation":[{"name":"Pathology Queensland Townsville University Hospital  Townsville Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2005.09.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03144.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104518"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.544"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678707.2020.1709441"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.90.6.862"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12776"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2018.09.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110594"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxx002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317650"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23143"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy1128"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.052"},{"key":"e_1_2_7_17_1","unstructured":"Australian Government Department of Health.Modified Monash Model.2020. 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