{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:46:02Z","timestamp":1791499562285,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Echinococcosis with multi\u2010organ\/disseminated involvement is rare in childhood. We aimed to evaluate the clinical and laboratory characteristics and prognosis in paediatric patients with echinococcosis having multiorgan\/disseminated involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We evaluated retrospectively children with echinococcosis with involvement of three or more organs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients were included in the study. The median age was 120 (range 71\u2013189) months. Three (23%) were diagnosed incidentally. Abdominal pain was seen in 5 (38.4%) patients, vomiting in 4 (30.7%), headache in 3 (23%), cough in 2 (15.3%), groin pain in 1 (7.6%), 1 (7.6%) had jaundice and 1 (7.6%) had fever. The median duration of complaints was 48 (0\u2013140) days. The most common tripartite organ was 38.4% (5\/13) liver, lung and spleen. Isolated abdominal dissemination was detected in two patients. Two patients had multi\u2010organ involvement and multiple cysts with dissemination. Cyst rupture was observed in three of the patients; recurrent urinary tract infection, hydroureteronephrosis, secondary peritonitis with intra\u2010abdominal abscess, and biliary tract fistula were each observed in one patient. Relapse developed in 3 (23%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Echinococcosis is a very slow growing and complex parasitic disease that affects many organs and tissues. In our study, eosinophilia, recurrence, and complications were seen at a higher rate in paediatric patients with multiorgan involvement, who required repetitive surgeries and long\u2010term medical treatment. However, there are scanty data on risk factors, optimum treatment and prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.15942","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T13:13:43Z","timestamp":1646745223000},"page":"1193-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi\u2010organ\/disseminated echinococcosis in children: Case series and review of the literature"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-878X","authenticated-orcid":false,"given":"\u00dcmm\u00fchan","family":"\u00c7ay","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious, Faculty of Medicine Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-2883","authenticated-orcid":false,"given":"Derya","family":"Alabaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious, Faculty of Medicine Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-7645","authenticated-orcid":false,"given":"\u00d6zlem","family":"\u00d6 G\u00fcnde\u015flioglu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious, Faculty of Medicine Cukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2469-9963","authenticated-orcid":false,"given":"Kamuran","family":"Tutu\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0924-5739","authenticated-orcid":false,"given":"Merve","family":"K \u00c7il","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Adana City Training and Research Hospital  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5871-0695","authenticated-orcid":false,"given":"Umur A","family":"Pehlivan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine \u00c7ukurova University  Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"WHO.Echinococcosis. Available from:https:\/\/www.who.int\/home\/newsroom\/factsheets\/detail\/namingthe-Echinococcosis[accessed 9 September 2021]"},{"key":"e_1_2_5_3_1","first-page":"2252","volume-title":"Feiginand Cherry's Textbook of Pediatric Infectious Diseases","author":"Serpa JA","year":"2018"},{"key":"e_1_2_5_4_1","unstructured":"MoroPL.Clinical manifestations and diagnosis of echinococcosis. Available from:http:\/\/www.uptodate.com\/contents\/Clinical-manifestations-and-diagnosis-of-echinococcosis[accessed October 2021]."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800731025"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001444"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_531_19"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-021-04904-3"},{"key":"e_1_2_5_9_1","first-page":"173","article-title":"Ten\u2010year follow\u2010up of children with hydatid cysts","volume":"54","author":"\u015ei\u015fmanlar Ey\u00fcbo\u011flu T","year":"2019","journal-title":"Turk. Pediatr. Ars."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526520666200228104316"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2019.05.009"},{"key":"e_1_2_5_12_1","first-page":"17","article-title":"Hydatid cysts in children: Analysis of 49 cases","volume":"22","author":"\u00d6zt\u00fcrk HH","year":"2006","journal-title":"Turk. J. Surg."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5152\/tpd.2016.4381"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/50.6.374"},{"key":"e_1_2_5_15_1","first-page":"292","article-title":"Unusual presentation of multi\u2010organ hydatid cysts in a child","volume":"36","author":"Cam I","year":"2019","journal-title":"Balkan Med. J."},{"key":"e_1_2_5_16_1","first-page":"65","article-title":"Multiple organ involvement with hydatid cysts","volume":"10","author":"Sabouni F","year":"2010","journal-title":"Iran. J. Parasitol."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.59362"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000168849.01362.03"},{"key":"e_1_2_5_19_1","article-title":"Disseminated hydatid disease in a child involving multiple organ systems: A case report","volume":"12","author":"Shabbir MU","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_5_20_1","first-page":"43","article-title":"Multiple organ involvement of hydatid cyst \u0130n 7\u2010year\u2010old girl","volume":"1","author":"Ta\u015f T","year":"2011","journal-title":"Int. Archives Med. Res."},{"key":"e_1_2_5_21_1","first-page":"7","article-title":"A pediatric case of desseminated cystic echinococcosis successfully treated with mebendazole","volume":"57","author":"Kaya Z","year":"2004","journal-title":"Jpn. J. Infect. Dis."},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmn054"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03532-4"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1039201"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020002"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.5505\/sakaryamj.2012.68442"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015458.2005.11679699"},{"key":"e_1_2_5_28_1","first-page":"265","article-title":"Recurrence of hydatid cyst of liver: Predictive factors: Tunisian experience","volume":"2012","author":"Bedioui H","year":"1990","journal-title":"Bulletin de la Soci\u00e9t\u00e9 de pathologie exotique"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15942","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.15942","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.15942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T04:21:35Z","timestamp":1692850895000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.15942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/jpc.15942"],"URL":"https:\/\/doi.org\/10.1111\/jpc.15942","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"2021-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}