{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:14:55Z","timestamp":1789802095657,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Paediatric eosinophilic gastritis (EG) is a rare disorder and existing literature on diagnostic criteria and management remains lacking. We aim to describe the clinical spectrum and assess the efficacy of dietary elimination and proton\u2010pump inhibitor (PPI) therapy, with particular emphasis on histologic remission in children with primary EG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective study of patients aged 0\u201318\u2009years diagnosed with EG at a single centre in Singapore from 2013 to 2021. EG was diagnosed based on histological criteria of infiltration of &gt;30 eosinophils per high\u2010power film (HPF) in &gt;5 separate HPFs from gastric biopsies, in the absence of other causes. First\u2010line treatment consisted of PPI therapy and empiric 1\u20136 food elimination diet (FED). Outcomes measured were clinical, endoscopic and histological remission (defined as eosinophil count &lt;20\/HPF in gastric biopsies).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010one (66.7% females) patients were included with median age at diagnosis of 15 months (range:3\u2013192). Majority presented with vomiting (76.2%) and gastrointestinal bleeding (71.4%). Twenty patients were initiated on FED+PPI and 16 had post\u2010treatment biopsies. Clinical, endoscopic and histologic remissions were achieved in 94.7%, 81.3% and 68.8% respectively following FED+PPI. Histologic remission was significantly associated with younger age (9 vs. 132 months;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.026). Four patients who did not respond to FED+PPI were started on oral viscous budesonide, of whom one achieved histological remission and two had clinical improvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FED+PPI is effective as first\u2010line treatment in achieving histological remission in paediatric EG particularly in younger patients. Topical corticosteroids can be considered for those who have failed FED+PPI therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.15969","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T08:11:06Z","timestamp":1649319066000},"page":"1244-1250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical, histopathological features and efficacy of elimination diet and proton\u2010pump inhibitor therapy in achieving histological remission in Asian children with eosinophilic gastritis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-1426","authenticated-orcid":false,"given":"Lay Q","family":"Ng","sequence":"first","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Pediatric Medicine KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyin","family":"Loh","sequence":"additional","affiliation":[{"name":"Allergy Service, Pediatric Medicine KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia X","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurshid","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-0267","authenticated-orcid":false,"given":"Fang K","family":"Chiou","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hepatology and Nutrition Service, Pediatric Medicine KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318181b1c3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.05.050"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.05.035"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181eb5a9f"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13463"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2350\/11-05-0130.1"},{"key":"e_1_2_6_8_1","first-page":"556","article-title":"Eosinophilic gastritis: Histopathological characterization and quantification of the normal gastric eosinophil content","volume":"17","author":"Lwin T","year":"2010","journal-title":"Mod. 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