{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:51:19Z","timestamp":1781106679111,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>There is a paucity of data on cerebrospinal fluid (CSF) procalcitonin (PCT) to diagnose neonatal meningitis. We evaluated CSF PCT to diagnose bacterial meningitis among neonates with suspected sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Neonates undergoing lumbar puncture (LP) as part of sepsis workup were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Index Tests<\/jats:italic>\n                      : CSF PCT, plasma PCT, CSF:plasma PCT ratio and CSF cytochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Reference Standards<\/jats:italic>\n                      : \u2018Definite meningitis\u2019 defined by positive CSF culture and\/or gram stain and\/or broad\u2010based primer 16S rDNA polymerase chain reaction. \u2018Definite or probable\u2019 meningitis is defined as definite meningitis or abnormal cytochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 216 eligible neonates, 18 had \u2018definite meningitis\u2019 and 37 \u2018definite or probable meningitis\u2019. Median (\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      ,\n                      <jats:italic>Q<\/jats:italic>\n                      <jats:sub>3<\/jats:sub>\n                      ) CSF PCT level was significantly higher in \u2018definite meningitis\u2019 compared to \u2018no definite meningitis\u2019 (0.429 (0.123, 1.300) vs. 0.181 (0.119, 0.286) ng\/mL respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.028). Likewise, it was significantly higher in \u2018definite or probable meningitis\u2019 compared to no meningitis (0.245 (0.136, 0.675) vs. 0.170 (0.116, 0.28),\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.01). The area under the receiver operator characteristics curve of CSF PCT level for definite meningitis was 0.656 and for \u2018definite or probable meningitis\u2019 0.635. Paired comparisons of area under the receiver operator characteristics curve of CSF PCT with the other index tests showed no significant differences. Based on\n                      <jats:italic>a priori<\/jats:italic>\n                      cut\u2010off of 0.2\u00a0ng\/mL, CSF PCT level had a sensitivity (95% confidence interval) of 67% (50, 80), specificity 58% (54, 61), LR\n                      <jats:sup>+<\/jats:sup>\n                      1.6 (1.1, 2.0) and LR\n                      <jats:sup>\u2212<\/jats:sup>\n                      0.6 (0.3, 0.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher values of CSF PCT are associated with neonatal bacterial meningitis. However, the diagnostic performance of CSF PCT is modest and not significantly different from standard tests.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.16023","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T07:47:28Z","timestamp":1654156048000},"page":"1425-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cerebrospinal fluid and plasma procalcitonin for the diagnosis of neonatal bacterial meningitis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-8289","authenticated-orcid":false,"given":"Sourabh","family":"Dutta","sequence":"first","affiliation":[{"name":"Department of Pediatrics Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallab","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181958755"},{"key":"e_1_2_7_3_1","unstructured":"Excellence NIfhac. 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