{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:10Z","timestamp":1747186750102,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Recognition of paediatric respiratory distress and timely intervention is critical, especially during the weaning phase of support in paediatric acute respiratory failure, as weaning too aggressively can lead to further setbacks in a patient's recovery. We aimed to determine if pulmonary function measurements obtained with the pneuRIP device, a noninvasive pulmonary function testing device that provides measurements of labored breathing index (LBI), phase angle and %rib cage (%RC) contribution to breathing, will provide predictive values to assess the adequacy of respiratory support while weaning from HFNC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed patients ages 0\u201318\u2009years admitted to the PICU for respiratory distress due to respiratory infections receiving HFNC. Patients with history of chronic lung disease and chronic neuromuscular disease with baseline habnormal breathing patterns were excluded. Phase angle, LBI and %RC were obtained every hour and with every wean of HFNC. Nine patients were enroled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean LBI range remained 1.27\u20131.68 when LBI was plotted as a function of the HFNC flow rate. Mean values of %RC contribution to breathing ranged 43.65\u201357.12 as a function of the HFNC flow rate. No significant deviations existed in either %RC (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.16) or LBI (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.16) during the weaning of HFNC. Mean phase angle for all subjects was 41.48\u00b0\u201374.12\u00b0 for the duration of wean and showed significant deviation from baseline during the weaning process (p\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Measurements of LBI and %RC on the pneuRIP device effectively demonstrated tolerance of weaning HFNC during the recovery phase of acute respiratory failure from a respiratory infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16031","type":"journal-article","created":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T10:29:11Z","timestamp":1654165751000},"page":"1548-1553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Utilising pneuRIP device in determining the adequacy of respiratory support when weaning high\u2010flow nasal cannula in paediatric patients with acute respiratory distress: A pilot study"],"prefix":"10.1111","volume":"58","author":[{"given":"Deepika K","family":"Murala","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nemours Children's Hospital, Delaware  Wilmington Delaware United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9541-2301","authenticated-orcid":false,"given":"Yosef","family":"Levenbrown","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Nemours Children's Hospital, Delaware  Wilmington Delaware United States"},{"name":"Department of Pediatrics Sidney Kimmel Medical School of Thomas Jefferson University  Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Nemours Biomedical Research, Nemours Children's Health  Wilmington Delaware United States"},{"name":"Department of Applied Economics and Statistics University of Delaware  Newark Delaware United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jobayer","family":"Hossain","sequence":"additional","affiliation":[{"name":"Nemours Biomedical Research, Nemours Children's Health  Wilmington Delaware United States"},{"name":"Department of Applied Economics and Statistics University of Delaware  Newark Delaware United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Nemours Biomedical Research\/Research Lung Center, Nemours Children's Health  Wilmington Delaware United States"},{"name":"Department of Pediatrics Sidney Kimmel Medical College at Thomas Jefferson University  Philadelphia Pennsylvania United States"},{"name":"Department of Pediatrics Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e3181d6db37"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23981"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0b013e31827122a9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05153"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04452"},{"key":"e_1_2_8_7_1","first-page":"197","article-title":"High\u2010flow nasal cannula use in a paediatric intensive care unit over 3\u2009years","volume":"17","author":"Wraight TI","year":"2015","journal-title":"Crit. Care Resusc."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01941"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0029-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2017.09.003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.05.022"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2018.03.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.2.454"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4035546"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24134"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.120"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/724139"},{"key":"e_1_2_8_18_1","unstructured":"R Core Team.R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Available from:https:\/\/www.R-project.org\/"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4276"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308723"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-642ST"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0226980"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-00977-z"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-020-1032-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238402"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08284"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:51:07Z","timestamp":1692647467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,2]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jpc.16031"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16031","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"type":"print","value":"1034-4810"},{"type":"electronic","value":"1440-1754"}],"subject":[],"published":{"date-parts":[[2022,6,2]]},"assertion":[{"value":"2022-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}