{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:39:10Z","timestamp":1747186750043,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to compare the efficacy of 3% versus 30% NaCl solution in treating umbilical granuloma (UG) and to evaluate parental satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised, double\u2010blinded, comparative study in neonates with UG was conducted. Stratified, block\u2010of\u2010four randomisation was used to allocate neonates into two groups, treated with 3% or 30% pharmaceutical\u2010grade NaCl solution, three times daily. The time to resolution was determined by daily photographs of UG and weekly hospital visits. If there was no response after 2\u2009weeks, silver nitrate was used. Parental satisfaction was measured on a rating scale of 1\u20135.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred neonates were enrolled, 48 in the 3% NaCl group and 52 in the 30% NaCl group. Baseline demographic data were not different between the groups. There was no significant difference in the resolution rate (93.8% vs 98.1%) or the median (interquartile range) time to resolution (7 (5\u201313) vs 7 (4\u201311) days) between the 3% and 30% NaCl groups, respectively. No skin burn or cellulitis was detected. About 95% of parents scored &gt;4 for satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hypertonic NaCl solution is highly effective in treating UG without side effects. Hypertonic NaCl solution should be considered as an alternative treatment for UG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16034","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T09:37:10Z","timestamp":1653989830000},"page":"1566-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Randomised comparative study on the efficacy of 3% versus 30% NaCl solution in the treatment of umbilical granuloma"],"prefix":"10.1111","volume":"58","author":[{"given":"Pornpimon","family":"Janyoungsak","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanuengnit","family":"Emrat","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidapa","family":"Chatmapanrangsee","sequence":"additional","affiliation":[{"name":"Division of Pharmacy Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-9445","authenticated-orcid":false,"given":"Pracha","family":"Nuntnarumit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"909","article-title":"Cryosurgery\u2010a new modality for the management of umbilical granuloma of newborn","volume":"18","author":"Seth SS","year":"1981","journal-title":"Indian Pediatr."},{"key":"e_1_2_7_3_1","first-page":"146","article-title":"The management of umbilical granulomas with cryocautery","volume":"144","author":"Sheth SS","year":"1990","journal-title":"Am. 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