{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:15:45Z","timestamp":1773288945531,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the clinical outcomes and evaluate the perspectives of children with Type 1 diabetes (T1D) and their parents managing their child on hybrid closed\u2010loop (HCL) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children with T1D on HCL attending a tertiary diabetes centre between April 2019 and July 2021 were included. A retrospective analysis of glycaemic data was conducted to determine the clinical outcomes. Time spent in closed loop, time in target glucose range (TIR 3.9\u201310\u2009mmol\/L), hypoglycaemia and hyperglycaemia were collected at baseline, 4\u2009weeks, 3 and 6\u2009months post\u2010HCL. User experience was assessed by questionnaires administered to parents of children with T1D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one children, mean (SD) age of 12.2 (3.2)\u00a0years were commenced on HCL. Ten (14%) discontinued HCL use, with 60% discontinuing within the first 6 months. Glycaemic outcomes were analysed in 52 children. Time spent in closed loop was 78 (21) % at 4\u2009weeks, declined to 69 (28) % at 3 months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.037) and 63 (34) % at 6\u2009months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The mean %TIR increased from 59.8 at baseline to 67.6 at 3 months and 65.6 at 6\u2009months with a mean adjusted difference of 7.8% points [95% CI 3.6, 11.9] and 5.5% points [95% CI 1.4, 9.5], respectively. There was a reduction in time\u2009&gt;\u200910\u2009mmol\/L and time\u2009&lt;\u20093.9\u2009mmol\/L from baseline to 6 months. Although families faced challenges with technology, better glucose control with reduced glycaemic fluctuations were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCL therapy is associated with improved glycaemia; however, adequate support and education are required for best outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16043","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T06:11:31Z","timestamp":1654063891000},"page":"1578-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of real\u2010life clinical outcomes in Australian youth with type 1 diabetes on hybrid closed\u2010loop therapy: A retrospective study"],"prefix":"10.1111","volume":"58","author":[{"given":"Sathyakala","family":"Vijayanand","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Broad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Paediatrics, within the Medical School The University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig E","family":"Taplin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Paediatrics, within the Medical School The University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy W","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Paediatrics, within the Medical School The University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3628-1735","authenticated-orcid":false,"given":"Mary B","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Perth Children's Hospital  Perth Western Australia Australia"},{"name":"Telethon Kids Institute University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Paediatrics, within the Medical School The University of Western Australia  Perth Western Australia 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