{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:23:00Z","timestamp":1750652580358,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The rapid spread of a novel human coronavirus SARS\u2010CoV\u20102 led to drastic measures world\u2010wide. Most countries were forced to declare a national lockdown. We studied the effect of lockdown measures on the level of asthma control and maintenance treatment in children with recurrent wheezing and asthma during the first wave of COVID\u201019 in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed children with recurrent wheezing or asthma before and after the implementation of the lockdown, by using a questionnaire aimed to examine pre\u2010existing respiratory disorders, step treatment and level of asthma control before\/after lockdown, COVID history and laboratory testing including IgG SARS\u2010CoV\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 475 asthmatic and pre\u2010school wheezers (60.6% males), mean age 5.6\u2009years. There were no differences in asthma treatment comparing both periods: 81.7% maintained the same treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.103). According to child asthma\u2010control questionnaire, 87.7% remained well controlled during confinement. Nearly, a third of children (34.9%) needed reliever treatment, mainly in older children. Determination of IgG SARS\u2010CoV\u20102 was performed in 233 children (49.1%) of whom 17 (7.3%) tested positive. Seven patients positive to IgG SARS\u2010CoV\u20102 were assisted in the emergency department and two required hospital admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>During COVID\u201019 lockdown in Spain, most children with recurrent wheezing and asthma remained well controlled from their underlying disease and did not modify greatly their maintenance treatments. Unexpectedly, we also observed that those children who tested positive to SARS\u2010CoV\u20102 IgG showed a significant increase in paediatric hospital admissions and attendances to urgent care settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16068","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:04:15Z","timestamp":1656065055000},"page":"1635-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of <scp>COVID<\/scp>\u201019 lockdown on children with recurrent wheezing and asthma in Spain"],"prefix":"10.1111","volume":"58","author":[{"given":"Zarife","family":"Daoud P\u00e9rez","sequence":"first","affiliation":[{"name":"Pediatrics Pulmonology Department HM Hospitals  Madrid Spain"},{"name":"Pediatrics Department Emirates Speciality Hospital Dubai  Dubai United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7063-2677","authenticated-orcid":false,"given":"Marcelo","family":"R\u00e1zquin Arias","sequence":"additional","affiliation":[{"name":"Pediatrics Pulmonology Department HM Nens, HM Hospitals  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-1429","authenticated-orcid":false,"given":"Alejandro","family":"L\u00f3pez\u2010Escobar","sequence":"additional","affiliation":[{"name":"Pediatrics Department Hospital Vithas Madrid La Milagrosa  Madrid Spain"},{"name":"Clinical Research Unit Fundaci\u00f3n Vithas, Grupo Vithas  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0631-3142","authenticated-orcid":false,"given":"Alvaro","family":"D\u00edaz\u2010Conradi","sequence":"additional","affiliation":[{"name":"Pediatrics Department HM Nens, HM Hospitals  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Arce","sequence":"additional","affiliation":[{"name":"Pediatrics Department HM Nens, HM Hospitals  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Pediatrics Pulmonology Department HM Nens, HM Hospitals  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Romero Blanco","sequence":"additional","affiliation":[{"name":"Pediatrics Department HM Hospitals  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"D\u00edaz\u2010Delgado","sequence":"additional","affiliation":[{"name":"Pediatrics Department HM Hospitals  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7981-8491","authenticated-orcid":false,"given":"Paula S","family":"Ventura Wichner","sequence":"additional","affiliation":[{"name":"Pediatrics Department HM Nens, HM Hospitals  Barcelona Spain"},{"name":"Pediatrics Department Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol (IGTP)  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"COVID\u201019 Map \u2013 Johns Hopkins Coronavirus Resource Center.2021; Nov 2. Available from:https:\/\/coronavirus.jhu.edu\/map.html"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2020.1781356"},{"key":"e_1_2_7_4_1","unstructured":"CDC COVID data tracker.Demographic trends of COVID\u201019 cases and deaths in the US reported to the CDC. Available from:www.cdc.gov\/covid-data-tracker\/index.html#demographics[accessed 18 October 2021]."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002660"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.115188"},{"key":"e_1_2_7_7_1","unstructured":"BOE.es \u2013 BOE\u2010A\u20102020\u20103692 Real Decreto 463\/2020 de 14 de marzo por el que se declara el estado de alarma para la gesti\u00f3n de la situaci\u00f3n de crisis sanitaria ocasionada por el COVID\u201019. Boe.es.2021; Aug 4. Available from:https:\/\/www.boe.es\/buscar\/doc.php?id=BOE-A-2020-3692"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20929"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584797"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.06.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02226-2020"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30167-3"},{"key":"e_1_2_7_13_1","unstructured":"CDC.People with moderate to severe asthma.Cdc.gov.2021. Available from:https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/asthma.html"},{"key":"e_1_2_7_14_1","unstructured":"Ginasthma.org.2021; Aug 5. Available from:https:\/\/ginasthma.org\/wp-content\/uploads\/2021\/03\/21_03_30-GINA-COVID-19-and-asthma.pdf"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.418"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.05.027"},{"key":"e_1_2_7_17_1","unstructured":"Propeller data shows 14.5% med adherence lift since COVID\u201019 outbreak began \u2013 Propeller Health.Propellerhealth.com.2020. Available from:https:\/\/www.propellerhealth.com\/press\/clinical-blog\/propeller-data-shows-14-5-med-adherence-lift-since-covid-19-outbreak-began\/"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25400"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2021.05.012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.053"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14787"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140353"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S233268"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2521-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab228"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-319910"},{"key":"e_1_2_7_27_1","unstructured":"Estudio ENE\u2010COVID: informe final estudio nacional de sero\u2010epidemiolog\u00eda de la infecci\u00f3n por sars\u2010cov\u20102 en Espa\u00f1a.2021; Aug 4. Available from:https:\/\/www.mscbs.gob.es\/ciudadanos\/ene-covid\/docs\/ESTUDIO_ENE-COVID19_INFORME_FINAL.pdf"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16068","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16068","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:51:45Z","timestamp":1692647505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/jpc.16068"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16068","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"type":"print","value":"1034-4810"},{"type":"electronic","value":"1440-1754"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"2021-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}