{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:21:52Z","timestamp":1785338512582,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Quality of life (QoL) in children with inflammatory bowel disease (IBD) is often impaired by underlying disease. We evaluated factors affecting health\u2010related QoL (HRQoL) in Malaysian children with IBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study using IMPACT\u2010III questionnaires evaluating HRQoL in children aged 8\u201317\u2009years with duration of IBD of \u22656\u00a0months was conducted. IMPACT\u2010III, a validated instrument designed to measure HRQoL in children with IBD, was used. Higher IMPACT\u2010III (maximum\u00a0=\u00a0100) score indicates better HRQoL. Impact of socio\u2010demographic and clinical factors of IBD on the HRQoL was evaluated. Paediatric Crohn's disease (CD) and ulcerative colitis (UC) activity indices were used to classify disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 75 children (UC\u00a0=\u00a044, CD\u00a0=\u00a041; mean (SD) age at diagnosis 8.2 (3.5) years) were interviewed at mean age of 12.8 (2.7) years. Mean IMPACT\u2010III score was significantly lower in children with more severe disease (mild: 71.8 (13.6) vs. moderate: 65.5 (10.9) vs. severe: 46.3 (14.5); <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001), history of hospitalisation (yes: 64.0 (14.0) vs. none: 74.1 (12.2), <jats:italic>P<\/jats:italic>\u00a0=\u20090.034) and a higher number of admissions (<jats:italic>r<\/jats:italic>\u00a0=\u2009\u22120.352, <jats:italic>P<\/jats:italic>\u00a0=\u20090.041) in preceding 6\u00a0months. Diagnosis at a younger age (<jats:italic>r<\/jats:italic>\u00a0=\u2009\u22120.31, <jats:italic>P<\/jats:italic>\u00a0=\u20090.007) and a longer duration of disease (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.286, <jats:italic>P<\/jats:italic>\u00a0=\u20090.013) was associated with higher score. A higher weight\u2010for\u2010age (<jats:italic>r<\/jats:italic>\u00a0=\u20090.261, <jats:italic>P<\/jats:italic>\u00a0=\u20090.023) or body mass index\u2010for\u2010age <jats:italic>z<\/jats:italic>\u2010score (<jats:italic>r<\/jats:italic>\u00a0=\u20090.235, <jats:italic>P<\/jats:italic>\u00a0=\u20090.042) was correlated with a better body image domain score, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Malaysian children with IBD, HRQoL was adversely affected by a more severe disease. Better control of disease activity and maintaining long\u2010term remission are important to improve the HRQoL in childhood IBD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16130","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T10:09:47Z","timestamp":1658830187000},"page":"1972-1979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quality of life in Malaysian children with inflammatory bowel disease: An understudied population"],"prefix":"10.1111","volume":"58","author":[{"given":"Gin W","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-6993","authenticated-orcid":false,"given":"Kee S","family":"Chew","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean Y","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sze Y","family":"Chong","sequence":"additional","affiliation":[{"name":"Paediatric Unit Hospital Raja Permaisuri Bainun  Ipoh Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sik Y","family":"Ong","sequence":"additional","affiliation":[{"name":"Paediatric Unit Hospital Tunku Azizah  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-2828","authenticated-orcid":false,"given":"Way S","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2021.07.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181b99baa"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12969-022-00664-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02496-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15667"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.04.045"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i6.1067"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14119"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2021.04.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbspro.2010.03.765"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200210000-00018"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002824"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i17.1830"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i25.2741"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000239"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000183350.46795.42"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.029"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2196\/16204"},{"key":"e_1_2_8_20_1","unstructured":"Malaysia DoS.Household Income and Basic Amenities Survey Report 20192019 2; September 2021. 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