{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:08:26Z","timestamp":1783490906039,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001530","name":"Canterbury Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Aseptic meningitis, including culture negative and viral meningitis, contributes a significant health\u2010care burden, including unnecessary antibiotic use and hospitalisation to treat possible bacterial meningitis. This study analysed aseptic meningitis hospitalisations in New Zealand (NZ) children over 29\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this population\u2010based study, aseptic meningitis hospitalisations in NZ children &lt;15\u2009years old were analysed from 1991 to 2020. Incident rate ratios were calculated using Poisson regression models. Variations in hospitalisations by age, year, sex, ethnicity, geographical region and socio\u2010economic deprivation were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 5142 paediatric aseptic meningitis hospitalisations from 1991 to 2020. Most were unspecified viral meningitis (64%), followed by enterovirus (29%). Hospitalisation rates varied annually with a median of 18.4\/100 000 children including a peak in 2001 of 56.4\/100 000 (51.7\u201361.6). From 2002 to 2019, rates increased by 8.4%\/year (7.2\u20139.5%) in infants &lt;90\u2009days old but decreased in all other age groups. In 2020, a reduction in hospitalisations to 9.6\/100 000 (7.9\u201311.8) occurred, and in infants &lt;90\u2009days old were 0.37 times expected. Hospitalisations were 1.50 times (1.49\u20131.68) higher in males than females; higher in children of M\u0101ori (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) and Pacific (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.001) versus European ethnicity; and higher for children living in the most (2.44 times, (2.16\u20132.75)) versus least deprived households; and in northern versus southern NZ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aseptic meningitis hospitalisations increased in young infants during 29\u2009years of surveillance, apart from 2020 when admissions reduced during the COVID\u201019 pandemic. In contrast, hospitalisations decreased in children aged &gt;1\u00a0year. Further investigation into reasons for higher admissions by ethnic group, geographical location and increased deprivation are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16131","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T08:29:36Z","timestamp":1658392176000},"page":"1980-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The epidemiology of aseptic meningitis in New Zealand children from 1991 to 2020"],"prefix":"10.1111","volume":"58","author":[{"given":"Michelia","family":"McBride","sequence":"first","affiliation":[{"name":"Department of Paediatrics University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-4435","authenticated-orcid":false,"given":"Jonathan","family":"Williman","sequence":"additional","affiliation":[{"name":"Department of Population Health University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Best","sequence":"additional","affiliation":[{"name":"Department of Paediatrics: Child and Youth Health University of Auckland  Auckland New Zealand"},{"name":"Department of Paediatric Infectious Diseases Starship Children's Hospital  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Walls","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sadarangani","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center BC Children's Hospital Research Institute  Vancouver British Columbia Canada"},{"name":"Department of Pediatrics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4032-7230","authenticated-orcid":false,"given":"Cameron C","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Paediatrics: Child and Youth Health University of Auckland  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-4602","authenticated-orcid":false,"given":"Natalie G","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University of Otago Christchurch  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.04.058"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306813"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002071"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1451810"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.08.062"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3280ad4672"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25807"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3077"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2083"},{"key":"e_1_2_8_11_1","unstructured":"Intergrated Data Infrastructure. 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