{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:52Z","timestamp":1788412732085,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effects of neurodevelopmental treatment (NDT) in children with congenital Zika syndrome (CZS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, interventional cohort study involved children with CZS undergoing follow\u2010up at a specialist centre in northeastern Brazil. The duration of the proposed NDT protocol was 1\u2009year, with 45\u2010min sessions delivered one to five times weekly. Motor function, weight, height, head circumference and the incidence of comorbidities were evaluated in children before protocol initiation and then at 3, 6 and 12\u2009months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty children were evaluated (age mean 30.1\u2009\u00b1\u20093\u00a0months). Motor function improved from baseline to 6\u2009months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).\u00a0No difference in weight and head circumference <jats:italic>z<\/jats:italic>\u2010score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.51 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.29, respectively), but an increase in height <jats:italic>z<\/jats:italic>\u2010score (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) was observed over the evaluation period. There was a reduction in the incidence of upper respiratory tract infections, pneumonia and urinary tract infections over the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NDT proved to be a viable treatment approach that can improve motor function and reduce the incidence of comorbidities in children with CZS, while having no harmful effects on their growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16139","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T09:03:51Z","timestamp":1659171831000},"page":"2008-2015","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of neurodevelopmental treatment in children with congenital Zika syndrome: A pilot study"],"prefix":"10.1111","volume":"58","author":[{"given":"Wirtud I M","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Associa\u00e7\u00e3o Brasileira de Abordagens Neurofuncionais (ABDAN)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-6711","authenticated-orcid":false,"given":"Gabriela L","family":"Gama","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"},{"name":"UNIFACISA University Center  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia C D","family":"Borges","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Brasileira de Abordagens Neurofuncionais (ABDAN)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara M A M","family":"Bastos","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Brasileira de Abordagens Neurofuncionais (ABDAN)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janiele S","family":"Tavares","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela S","family":"Barros","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jousilene S","family":"Tavares","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania M R","family":"Amorim","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Melo","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"},{"name":"UNIFACISA University Center  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2019.1656503"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.02.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14227"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602412"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/17518423.2018.1437843"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14307"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815576792"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000194"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7235"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01942638.2019.1600100"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2329048X19896190"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.08.016"},{"key":"e_1_2_8_15_1","unstructured":"Center for Disease Control and Prevention.Understanding Zika Virus Test Results. 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