{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:17:39Z","timestamp":1780085859761,"version":"3.54.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T00:00:00Z","timestamp":1660953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Leukopenia (lymphopenia or neutropenia) may be an important marker of altered immunity and risk in children with critical illness. We aimed to evaluate the prevalence, course, and outcome of leukopenia in children admitted to Paediatric Intensive Care Unit (PICU).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All consecutive children (<jats:italic>n<\/jats:italic>\u00a0=\u2009200) admitted to PICU for any reason except malignancy or pre\u2010existing immune deficiency were enrolled during June\u2013August 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median (interquartile range) age was 2.2 (0.6\u20138.5) years. About 52% (<jats:italic>n<\/jats:italic>\u00a0=\u2009103) had undergone a surgical procedure; 34% (<jats:italic>n<\/jats:italic>\u00a0=\u200968) being cardiac surgery. Among medical illnesses, respiratory disorders were the most common (<jats:italic>n<\/jats:italic>\u00a0=\u200939, 20%). Laboratory confirmed infections were present in 63 (31.5%) children. Leukopenia was identified in 135 (67.5%) children in the first week; 117 (58.5%) had only lymphopenia, 16 (8%) had both lymphopenia and neutropenia, and 2 (1%) had only neutropenia. In 69 children who had follow\u2010up blood counts, lymphopenia resolved in 33 (48%) within 48\u2009h and in another 20 (29%) by 4\u2009days, and in a further 10 (14%) by 7\u2009days. Children with lymphopenia had higher frequency of cardiac surgery, longer cardiopulmonary bypass time, greater need for invasive ventilation and vasopressor\/inotrope therapy, and a higher probability of organ failure on day 4 and longer hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In critically ill children, lymphopenia is very common, often transient, but may be associated with unfavourable outcomes. Further studies with follow\u2010up of blood counts in a larger sample are required to determine the course and outcomes of lymphopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16183","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T10:33:40Z","timestamp":1660991620000},"page":"2203-2210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and outcome of lymphopenia in the <scp>Paediatric Intensive Care Unit<\/scp>: A prospective observational study"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6713-9846","authenticated-orcid":false,"given":"Karthi","family":"Nallasamy","sequence":"first","affiliation":[{"name":"Pediatric Intensive Care Unit Postgraduate Institute of Medical Education and Research  Chandigarh 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