{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:26Z","timestamp":1747186646342,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["V.25011\/262\/2013\u2010HR"],"award-info":[{"award-number":["V.25011\/262\/2013\u2010HR"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Adequate vitamin B12 levels in infancy are crucial for normal psychomotor and cognitive development of infants. Our aim was to examine serum vitamin B12, folate and ferritin levels in exclusively breastfed healthy full\u2010term infants (age group: 1\u20136\u00a0months), and also investigate their correlation with maternal markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted on 100 exclusively breastfed healthy full\u2010term infants (age group: 1\u20136\u00a0months) along with their lactating mothers. Serum vitamin B12, folate and ferritin levels were determined for each mother\u2013infant dyad using enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum vitamin B12, folate and ferritin levels were 512 vs. 535\u2009pg\/mL, 15 vs. 12\u2009ng\/mL and 313 vs. 114\u2009ng\/mL in infants and mothers, respectively. Among 100 infants, 26 (26%) had lower vitamin B12 levels and 5 (5%) had inadequate folate levels. In addition, 22 (22%) of 100 lactating mothers were deficient in vitamin B12 levels and 14 (14%) had inadequate folate levels. We found a statistically significant positive correlation between infant and maternal vitamin B12 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.659, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and folate levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.51, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitamin B12 deficiency was observed in 26% of infants and 22% of lactating mothers. Vitamin B12 and folate levels of infants were positively correlated with maternal levels in the state of Punjab, North\u2010West India. Our findings support that maternal vitamin B12 status can be used as a valuable predictor of infant vitamin B12 status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16207","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T14:15:06Z","timestamp":1663078506000},"page":"2243-2247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Correlations between serum vitamin <scp>B12<\/scp> and folate levels among <scp>mother\u2013infant<\/scp> dyads in Punjab state, <scp>North\u2010West<\/scp> India"],"prefix":"10.1111","volume":"58","author":[{"given":"Inderpal S","family":"Grover","sequence":"first","affiliation":[{"name":"Department of Pharmacology Government Medical College  Amritsar Punjab India"},{"name":"Multidisciplinary Research Unit Government Medical College  Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Government Medical College  Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renu","family":"Kapahi","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry Government Dental College and Hospital  Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manmeet K","family":"Sodhi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Government Medical College  Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-9142","authenticated-orcid":false,"given":"Ruhi","family":"Kapahi","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit Government Medical College  Amritsar Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343114"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.232"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.3.624"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.143917"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001172"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.012021"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/156482650702800409"},{"key":"e_1_2_10_11_1","first-page":"380","article-title":"Vitamin B12 and folic acid: Significance in human health","volume":"52","author":"Laxmaiah A","year":"2015","journal-title":"Indian Pediatr."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0379572117697535"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-020-03413-w"},{"volume-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","year":"2006","author":"Burtis CA","key":"e_1_2_10_14_1"},{"volume-title":"Vitamin and Mineral Nutrition Information System","year":"2015","author":"WHO","key":"e_1_2_10_15_1"},{"volume-title":"The Harriet Lane Handbook: A Manual for Pediatric House Officers","year":"2015","author":"Flerlage J","key":"e_1_2_10_16_1"},{"key":"e_1_2_10_17_1","first-page":"69","article-title":"Statistics corner: A guide to appropriate use of correlation coefficient in medical research","volume":"24","author":"Mukaka MM","year":"2012","journal-title":"Malawi Med. 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