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Guidelines in the United States and Europe now include definitions guiding the identification of acute severe hypertension (otherwise known as hypertensive crisis) and its management. This review discusses these recommendations and the appropriate use of oral antihypertensive agents for children with minimal or no symptoms. We focus on the role of oral calcium channel blockers, including isradipine (a second\u2010generation dihydropyridine), given recent changes to regulatory approvals in Australia. The differing pharmacokinetic and pharmacodynamic properties of agents are compared, with the aim of facilitating directed drug selection and dosing.<\/jats:p>","DOI":"10.1111\/jpc.16210","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T11:24:37Z","timestamp":1663759477000},"page":"1935-1941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral agents for acute severe hypertension in children with minimal or no symptoms"],"prefix":"10.1111","volume":"58","author":[{"given":"Sally","family":"Hijazzi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwi","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G","family":"Larkins","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Perth Children's Hospital  Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001039"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja16.00526"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1904"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1698759"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-016-0040-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(10)60009-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.9.1089"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00111-8"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.588911"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000126"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-020-01423-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.08.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0590"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00792-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000480"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1331\/108658002762063709"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199819020-00003"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114699"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670200006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1444-x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-019-00377-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-002-0939-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1988.tb03195.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.7.645"},{"key":"e_1_2_9_26_1","first-page":"2409","article-title":"Stability of isradipine in an extemporaneously compounded oral liquid","volume":"51","author":"MacDonald JL","year":"1994","journal-title":"Am. 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