{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:04:28Z","timestamp":1791497068885,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T00:00:00Z","timestamp":1663372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Early onset sepsis (EOS) in preterm infants is associated with high morbidity and mortality. Improved characterisation of the haemodynamic presentation of EOS could lead to more effective and targeted treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective observational study of preterm infants \u226432\u2009week' gestation with EOS between 2010 and 2020 and gathered clinical, haemodynamic and echocardiographic data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2198 admitted infants, 27 infants (median gestational age 28\u2009weeks, median birthweight 1174\u2009g) developed EOS with predominantly gram\u2010negative pathogens and the overall mortality rate was 33.3%. Besides hypotension, clinical signs were non\u2010specific, and over half of infants were normotensive in the first 72\u2009h of life. Those with hypotension received more fluid resuscitation, inotropic support and had a higher mortality compared to the normotensive infants. Cardiac ultrasound was available in 18 infants and commonly revealed higher as expected cardiac output, pulmonary hypertension and diastolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preterm infants with EOS had a high mortality rate, especially when they progressed from sepsis to septic shock. Echocardiography revealed a normal haemodynamic pattern, or one suggestive of vasodilatation and warm shock physiology. Targeting this pathophysiology earlier might improve outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16218","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T07:24:17Z","timestamp":1663399457000},"page":"2267-2272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and haemodynamic characteristics of preterm infants with early onset sepsis"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-3253","authenticated-orcid":false,"given":"Niall","family":"Johnston","sequence":"first","affiliation":[{"name":"Department of Neonatology John Hunter Children's Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-1482","authenticated-orcid":false,"given":"Koert","family":"de Waal","sequence":"additional","affiliation":[{"name":"Department of Neonatology John Hunter Children's Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-052456"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.0593"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.04.002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01855-2"},{"key":"e_1_2_7_6_1","first-page":"5","article-title":"Ventricular function and high\u2010sensitivity cardiac troponin T in preterm infants with neonatal sepsis","volume":"55","author":"Ramadhina N","year":"2015","journal-title":"Paediatr. 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