{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:29:20Z","timestamp":1784302160646,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To find out the relative incidence and outcome of posterior fossa abnormality (PFA) in terms of survival at birth until 2\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study; all fetuses diagnosed with posterior fossa abnormality were followed\u2010up. The outcome was observed with respect to survival, the presence of associated anomalies, the existence of developmental delay after a telephonic interview.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 2703 children with congenital anomalies, 921 (34.1%) had a central nervous system defect;\u00a076 cases of PFA were fully followed. Dandy\u2013Walker malformation (DWM) was present in 50% (38\/76), mega cisterna magna 18.4% (14\/76), Blake pouch cyst 13.2% (10\/76), vermian hypoplasia (VH) 13.2% (10\/76) and arachnoid cyst 5.2% (4\/76). The diagnosis was possible before 20\u2009weeks in only 12 (15.8%) cases.\u00a0The mean gestational age at delivery was 34.7\u2009\u00b1\u20096.7\u2009weeks. Associated anomalies were seen in 35\/76 (46.1%) cases. A total of 35\/76 (46.1%) survived after 2\u2009years; there was developmental delay in 9.2% of cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is a large variation in the outcome of PFA depending upon the type of anomaly. Associated anomalies are common in VH and DWM, making their prognosis worse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16254","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T21:14:30Z","timestamp":1667337270000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Relative prevalence and outcome of fetal posterior fossa abnormality"],"prefix":"10.1111","volume":"59","author":[{"given":"Nikita","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Paediatrics Southern Illinois University  Carbondale Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-2020","authenticated-orcid":false,"given":"Manisha","family":"Kumar","sequence":"additional","affiliation":[{"name":"Fetal Medicine Subdivision, Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pathology LHMC  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivangi Shanker","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology LHMC  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-2818","authenticated-orcid":false,"given":"Amit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pediatric surgery AIIMS  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Roy Chaudhary","sequence":"additional","affiliation":[{"name":"Pediatric Surgery KSCH  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000229501"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4179"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2196"},{"key":"e_1_2_9_5_1","first-page":"161","article-title":"Incidence of consanguinity and its effects on fertility and morbidity in Indian region: A reappraisal","volume":"3","author":"Bhasin MK","year":"1994","journal-title":"J. Hum. Ecol."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355401"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812223192501"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.15406\/ipcb.2017.02.00013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1485"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0782-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200004)20:4<328::AID-PD806>3.0.CO;2-O"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000100790"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077963"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1722"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142146"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1997.10030167.x"},{"key":"e_1_2_9_17_1","first-page":"436","article-title":"Enlarged cisterna magna and the Dandy\u2010Walker malformation: Factors associated with chromosome abnormalities","volume":"77","author":"Nyberg DA","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15755"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:20:39Z","timestamp":1692469239000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jpc.16254"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16254","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}