{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:11Z","timestamp":1783486211108,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Recently, there has been debate about reducing newborn screening (NBS) thyroid\u2010stimulating hormone (TSH) cut\u2010offs to identify children with mild, but potentially clinically significant, thyroid deficiency. Once identified by NBS, these children will be referred to paediatric endocrinologists for further testing and possible treatment; however, variation in current clinical practice is not known. The aim of this study is to survey Paediatric Endocrinologists in Australia and New Zealand to gain insight into clinical practice for the treatment of mild thyroid deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A piloted questionnaire was sent to members of the Australasian Paediatric Endocrinologist Group. The survey asked the Australasian Paediatric Endocrinologist Group members about the investigations performed, treatment and follow\u2010up for infants with different confirmatory serum TSH levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 42 completed surveys, a response rate of 34%. When presented with four case studies, 7% of clinicians would treat a child with confirmatory serum TSH of 8.7\u00a0mU\/L with thyroxine, 69% would treat a child with confirmatory serum TSH 21.4\u00a0mU\/L, 76% would treat a child with confirmatory serum TSH 24.3\u00a0mU\/L and 95% would treat a child with confirmatory serum TSH 44.7\u00a0mU\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This contemporary survey of clinicians regarding the treatment of mild thyroid deficiency in children has shown that clinical practice varies extensively. International and national guidelines on the treatment of congenital hypothyroidism should be updated to incorporate new evidence and ensure consistency across clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16259","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T06:00:05Z","timestamp":1666936805000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical survey of current practice regarding treatment of children with borderline thyroid abnormalities"],"prefix":"10.1111","volume":"59","author":[{"given":"Samantha","family":"Lain","sequence":"first","affiliation":[{"name":"Children's Hospital at Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Nassar","sequence":"additional","affiliation":[{"name":"Children's Hospital at Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Jack","sequence":"additional","affiliation":[{"name":"Department Paediatric Endocrinology, Northern Clinical School, Royal North Shore Hospital University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0777"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0107"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-019-02867-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03828-9"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu7115450"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa415"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30122-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.147884"},{"key":"e_1_2_9_10_1","volume-title":"Guidelines for the Management of Congenital Hypothyroidism","author":"Australian Paediatric Endocrine Group","year":"2007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2020.0333"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0915"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1903"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-8-15"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0326"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2009.22.11.1017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000172"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16259","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16259","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16259","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:20:53Z","timestamp":1692469253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jpc.16259"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16259","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"2022-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}