{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:43:07Z","timestamp":1774928587406,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the size of the corpus callosum (CC) and cerebellum on magnetic resonance imaging (MRI) brain scans conducted at term equivalent age (TEA) in extremely preterm infants who received systemic postnatal corticosteroids (PCS) to extremely preterm infants who did not receive systemic PCS and determine the dose\u2010dependent effects on these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Single\u2010centre retrospective cohort study including extremely preterm infants (born\u2009&lt;\u200926\u2009weeks' gestation) who had MRI brain scans at TEA. CC and cerebellar measurements were evaluated by two radiologists who were blinded to steroid use and their independent measurements were averaged. Comparative analyses were conducted between exposed (to systemic PCS) and non\u2010exposed groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010three extremely preterm infants with mean (SD) 24.9 (0.91) weeks' gestational age, 721.8 (156) g birthweight were included; 38 with systemic PCS exposure and 45 without exposure. After adjustment for birthweight and other significant neonatal morbidities, there was no significant difference noted in corpus callosum length (CCL) between unexposed and exposed groups (adjusted mean (SE) 39.5 (0.57) mm vs. 38.5 (0.62) mm; <jats:italic>P<\/jats:italic>\u00a0=\u20090.29). Similarly, the ratios of CCL\/fronto\u2010occipital diameter (FOD) and CCL\/biparietal diameter (BPD) were not significantly different between the groups (CCL\/FOD (0.40 (0.01) vs. 0.41 (0.01); <jats:italic>P<\/jats:italic>\u00a0=\u20090.70) and CCL\/BPD (0.51 (0.01) vs. 0.52 (0.01); <jats:italic>P<\/jats:italic>\u00a0=\u20090.62)). Finally, no significant differences in cerebellar measurements, such as vermian height (adjusted mean (SE) 24.0 (0.46) mm vs. 23.5 (0.51\u2009mm); <jats:italic>P<\/jats:italic>\u00a0=\u20090.47) and transcerebellar diameter (adjusted mean (SE) 49.3 (0.74) mm vs. 4.78 (0.82) mm; <jats:italic>P<\/jats:italic>\u00a0=\u20090.22) were found. No dose\u2010dependent effects of systemic PCS on CC and cerebellar measurements were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systemic PCS use in extremely preterm infants was not associated with a change in the CC and cerebellar measurements on MRI brain scan at TEA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16286","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T07:19:57Z","timestamp":1669015197000},"page":"282-287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systemic postnatal corticosteroids and magnetic resonance imaging measurements of corpus callosum and cerebellum of extremely preterm infants"],"prefix":"10.1111","volume":"59","author":[{"given":"Charmaine","family":"Han\u2010Menz","sequence":"first","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Whiteley","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Evans","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6185-3694","authenticated-orcid":false,"given":"Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"},{"name":"Monash Newborn Monash Children's Hospital  Melbourne Victoria Australia"},{"name":"Ritchie Centre Hudson Institute of Medical Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9664-4182","authenticated-orcid":false,"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Monash University  Melbourne Victoria Australia"},{"name":"Monash Newborn Monash Children's Hospital  Melbourne Victoria Australia"},{"name":"Ritchie Centre Hudson Institute of Medical Research  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2843"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-1354"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-1-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.10.083"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22874"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13364"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15670"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.11.057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.655164"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073819847925"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.04.059"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/124.1.60"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002884"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-018-0946-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.101646"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181b3aec5"},{"key":"e_1_2_7_18_1","first-page":"Cd001146","article-title":"Early (<8\u2009days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants","volume":"10","author":"Doyle LW","year":"2017","journal-title":"Cochrane Database Syst. 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