{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:25:27Z","timestamp":1789507527795,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Neonatal jaundice is an important and prevalent condition that can cause kernicterus and mortality. This study validated a smartphone\u2010based screening application (Biliscan) in detecting neonatal jaundice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional prospective study was conducted at the neonatal unit in a tertiary teaching hospital between August 2020 and October 2021. All babies born at the gestation of 35\u2009weeks and above with clinical jaundice or are recommended for screening of jaundice within 21\u2009days of post\u2010natal age were recruited. Using Biliscan, images of the babies' skin over the sternum were taken against a standard colour card. The application uses feature extraction and machine learning regression to estimate the bilirubin level. Independent Biliscan bilirubin estimates (BsB) were made and compared with total serum bilirubin (TSB) and transcutaneous bilirubin (TcB) levels. Bland Altman plots were used to establish the agreement between BsB and TSB, as well as TcB, using the clinically acceptable limits of agreement of \u00b135\u2009\u03bcmol\/L, which were defined <jats:italic>a priori<\/jats:italic>. Pearson correlation coefficient was assessed to establish the strength of the relationship between BsB versus TSB and TcB. Diagnostic accuracy was assessed through receiver operating characteristic curve analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one paired TSB\u2010BsB and 85 paired TcB\u2010BsB measurements were obtained. Bland Altman plot for the entire group showed that 54% (33\/61) of the pairs of TSB and BsB readings and 66% (56\/85) of the pairs of TcB and BsB readings were within the maximum clinically acceptable difference of 35\u2009\u03bcmol\/L. Pearson r for BsB versus TSB and TcB was 0.54 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 0.66 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) respectively. Compared with TSB, the recommended gold standard measure for jaundice, Biliscan has a sensitivity of 76.92% and specificity of 70.83% for jaundice requiring phototherapy. The positive and negative predictive values in term infants were 93.3% and 36.9%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that there is moderate correlation and mediocre agreement between BsB and TSB, as well as TcB. Improvement to the application algorithm and further studies that include a larger population, and a wider range of bilirubin values are necessary before the tool may be considered for use in screening of jaundice in newborns.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16287","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:54:58Z","timestamp":1669632898000},"page":"288-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Validation of a smartphone\u2010based screening tool (Biliscan) for neonatal jaundice in a multi\u2010ethnic neonatal population"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-4402","authenticated-orcid":false,"given":"Alvin Jia Hao","family":"Ngeow","sequence":"first","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Grace","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoao","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vina","family":"Tagamolila","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imelda","family":"Ereno","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih Yann","family":"Tay","sequence":"additional","affiliation":[{"name":"Nursing Division Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xin","sequence":"additional","affiliation":[{"name":"Health Services Research Unit Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woei Bing","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheo Lian","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Neonatal and Developmental Medicine Singapore General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.775"},{"key":"e_1_2_8_3_1","article-title":"Jaundice in the full\u2010term newborn","volume":"32","author":"Cohen SM","year":"2006","journal-title":"Pediatr. 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Med."},{"key":"e_1_2_8_19_1","first-page":"597","article-title":"Evaluation of an automatic image\u2010based screening technique for neonatal hyperbilirubinemia","volume":"54","author":"Rong Z","year":"2016","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20175928"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v40i3.29412"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","unstructured":"De GreefL GoelM SeoMJet al.Bilicam: Using mobile phones to monitor newborn jaundice. 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