{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:19:10Z","timestamp":1784931550011,"version":"3.55.0"},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Aminoglycosides are among the most commonly prescribed antibiotics in hospitalised Australian adults and children. A proportion of individuals with an underlying genetic predisposition to aminoglycoside\u2010induced hearing loss (AIHL) can develop bilateral sensorineural hearing loss that is immediate and profound after just a single standard dose of an aminoglycoside. A recent publication described the use of a rapid point\u2010of\u2010care test (POCT) in a neonatal nursery in the United Kingdom for real\u2010time detection of infants at risk of AIHL, in whom exposure to aminoglycosides could then be avoided. This proof of concept study should provide a catalyst for further development of similar assays that would be suitable for Australia's genetically diverse population. The barriers to mitigating the impact of AIHL on Australian children are not primarily technical, but involve a lack of data on the prevalence of the <jats:italic>MT\u2010RNR1<\/jats:italic> mutations in our current neonatal and paediatric populations and intensive care nurseries.<\/jats:p>","DOI":"10.1111\/jpc.16302","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T08:24:07Z","timestamp":1670228647000},"page":"9-11","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Using a bedside test to detect genetic susceptibility to aminoglycoside\u2010induced hearing loss: Has the future arrived?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-4113","authenticated-orcid":false,"given":"Meryta L","family":"May","sequence":"first","affiliation":[{"name":"Department of Microbiology, Sullivan Nicolaides Pathology Sonic Healthcare Australia  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Osowicki","sequence":"additional","affiliation":[{"name":"Tropical Diseases Research Group Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Infectious Diseases Unit Royal Children's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duaa","family":"Gaafar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Ballarat Base Hospital  Ballarat Central Victoria Australia"},{"name":"Murdoch Children's Research Institute University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme","family":"Suthers","sequence":"additional","affiliation":[{"name":"Sonic Healthcare Australia \u2013 Pathology  Sydney New South Wales Australia"},{"name":"Faculty of Health and Medical Sciences University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja13.00154"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000719"},{"key":"e_1_2_7_4_1","unstructured":"Deloitte Access Economic.The Social and Economic Cost of Hearing Loss in Australia; for Hearing Care Industry Assoication; 2017. Available from:https:\/\/apo.org.au\/node\/102776[accessed May 2022]."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2309"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2022.0187"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1243"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.08.003"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16302","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:22:27Z","timestamp":1692469347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/jpc.16302"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16302","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]},"assertion":[{"value":"2022-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}