{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:20:00Z","timestamp":1781194800020,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate MIS\u2010C patients' clinical manifestations, laboratory test results and mortality outcomes in an Egyptian tertiary care university hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 12 month cross\u2010sectional study in a tertiary\u2010care university children's hospital. All paediatric patients (1\u00a0month to 16\u2009years old) who met the CDC criteria for MIS\u2010C were enrolled in the\u00a0study. We assessed patients' clinical presentations, complications, treatments, imaging studies, laboratory test results and outcomes. The baseline clinical and laboratory findings of survivors and non\u2010survivors were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 45 MIS\u2010C patients, 24 (53.3%) were males, and the median (interquartile range) age was 4 (1.25\u201310) years. All patients had fever, 64.4% had respiratory manifestations, 48.9% presented with coma, 44.4% presented with shock, 33.3% presented with seizures, 31.1% had abdominal pain, 28.9% had vomiting and 22.2% presented with cerebrovascular stroke. A total of 15 (33.3%) patients died, and the non\u2010survivors had a significantly higher incidence of respiratory manifestations (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028), shock (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.034), cerebrovascular stroke (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) and seizures (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.044) as compared to the survivors. In addition, the serum levels of ferritin (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047), alanine aminotransferase (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047) and aspartate aminotransferase (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05) were significantly higher in the non\u2010survivors as compared to the survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on our findings, MIS\u2010C associated with COVID\u201019 is a potentially fatal illness. Hospitalised patients with MIS\u2010C often have multi\u2010organ injuries affecting the respiratory, cardiovascular, gastrointestinal and neurological systems. The deceased are more likely to exhibit respiratory manifestations, shock, cerebrovascular stroke, seizures and elevated serum levels of ferritin and liver enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16311","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T15:53:25Z","timestamp":1672329205000},"page":"445-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical and laboratory characteristics of multisystem inflammatory syndrome in children associated with <scp>COVID\u201019<\/scp> in Egypt: A tertiary care hospital experience"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-6391","authenticated-orcid":false,"given":"Tarek A","family":"Abdelaziz","sequence":"first","affiliation":[{"name":"Pediatric Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia A","family":"Abdulrahman","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5086-3312","authenticated-orcid":false,"given":"Eman G","family":"Baz","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M","family":"Allam","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina E","family":"Hamed","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology, Andrology Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf E A","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Anaesthesia and Critical Care Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud M","family":"Gohary","sequence":"additional","affiliation":[{"name":"Pediatric Department, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2020.4573"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.43151"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053418"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.5298"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13434"},{"key":"e_1_2_9_7_1","article-title":"Vitamin D in Corona virus disease 2019 (COVID\u201019) related multisystem inflammatory syndrome in children (MIS\u2010C)","volume":"8","author":"Feketea G","year":"2021","journal-title":"Front. Immunol."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100527"},{"key":"e_1_2_9_9_1","unstructured":"Multisystem Inflammatory Syndrome in Children (MIS\u2010C).Information for Healthcare Providers About Talking with Families and Caregivers. Available from:https:\/\/www.cdc.gov\/mis\/mis-c\/hcp\/provider-families.html"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"Multisystem inflammatory syndrome in children (MIS\u2010C) and neonates (MIS\u2010N) associated with COVID\u201019: Optimizing definition and management","volume":"1","author":"Molloy EJ","year":"2022","journal-title":"Pediatr. Res."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0274104"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41454"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41616"},{"key":"e_1_2_9_14_1","volume-title":"COVID Data Tracker","author":"Centers for Disease Control and Prevention","year":"2022"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa127"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-022-2559-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15913"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00050-X"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002777"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048360"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2022.2078230"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.912784"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-022-03308-z"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/08850666221092302"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmac025"},{"key":"e_1_2_9_28_1","unstructured":"MBFSon K.Friedman.Coronavirus disease 2019 (COVID\u201019): Multisystem inflammatory syndrome in children (MIS\u2010C) clinical features evaluation and diagnosis. UpToDate; 2022. Available from:https:\/\/www.uptodate.com\/contents\/covid\u201019\u2010multisystem\u2010inflammatory\u2010syndrome\u2010in\u2010children\u2010mis\u2010c\u2010clinical\u2010features\u2010evaluation\u2010and\u2010diagnosis?search=COVID19:%20Multisystem%20inflammatory%20syndrome%20in%20children%20(MISC)&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1"},{"key":"e_1_2_9_29_1","unstructured":"Network CDC.Multisystem Inflammatory Syndrome in Children (MIS\u2010C) Associated with Coronavirus Disease 2019 (COVID\u201019). Atlanta GA: U.S. Department of Health and Human Services. Centers for Disease Control and Prevention;2020. Available from:https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.045"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-021-02974-9"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333794X21990339"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmab015"},{"key":"e_1_2_9_35_1","unstructured":"CDC.Interim Guidelines for COVID\u201019 Antibody Testing. Atlanta GA: U.S. Department of Health and Human Services. Centers for Disease Control and Prevention;2022. Available from:https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/lab\/resources\/antibody-tests-guidelines.html"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2516"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.12.010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0504"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049836"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-021-05030-y"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01602-3"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217960"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40124-021-00258-5"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.16129"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15675"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31526"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jpc.16311","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:16:10Z","timestamp":1692638170000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/jpc.16311"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16311","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}