{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:31:42Z","timestamp":1791901902661,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Probiotic supplementation in the neonatal period results in improved gut colonisation with probiotic bacteria in the short term. There is limited information on the long\u2010term sustainability of this colonisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate whether oral probiotic supplementation in the neonatal period results in sustained gut colonisation with probiotic bacteria at or beyond 6\u00a0months after its cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of neonatal probiotic randomised controlled trials (RCTs) that reported on the stool microbiota during post\u2010discharge follow\u2010up was carried out using guidelines of the Cochrane neonatal group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009605 infants) were included in the review. The studies were heterogeneous in case selection, choice of probiotics, duration of supplementation, timing and the method of stool microbial analysis. Three RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009471) showed the presence of intestinal probiotic bacteria at 6\u201012 months. The overall certainty of evidence was very low in view of small sample size, heterogeneity and identification only to the genus\/species level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low certainty of evidence suggests that probiotic supplementation in the neonatal period may result in sustained gut colonisation 6\u201012 months post\u2010cessation, but not at 24 months. Adequately powered, well\u2010designed RCTs with strain\u2010specific assays are needed in this area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.16318","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T06:23:44Z","timestamp":1673418224000},"page":"212-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Probiotic supplementation in neonates and long\u2010term gut colonisation: A systematic review of randomised controlled trials"],"prefix":"10.1111","volume":"59","author":[{"given":"Ravisha","family":"Srinivasjois","sequence":"first","affiliation":[{"name":"Curtin School of Population Health Curtin University  Bentley Western Australia Australia"},{"name":"Department of Paediatrics and Neonatology Joondalup Health Campus  Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Health Sciences Edith Cowan University  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanuel","family":"Gebremedhin","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health Curtin University  Bentley Western Australia Australia"},{"name":"Enable Institute Curtin University  Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Neonatology Joondalup Health Campus  Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shripada","family":"Rao","sequence":"additional","affiliation":[{"name":"School of Medicine University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Neonatology Perth Children's Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Pereira","sequence":"additional","affiliation":[{"name":"Curtin School of Population Health Curtin University  Bentley Western Australia Australia"},{"name":"Enable Institute Curtin University  Bentley Western Australia Australia"},{"name":"Centre for Fertility and Health (CeFH) Norwegian Institute of Public Health  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442936"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-017638"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.574137"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.616713"},{"key":"e_1_2_6_6_1","unstructured":"Higgins JPT Thomas J Chandler J Cumpston M Li T Page MJ Welch VA.Cochrane Handbook for Systematic Reviews of Interventionsversion 6.3 (updated February 2022). 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