{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:40Z","timestamp":1747186660606,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify the risk factors associated with intussusception in children with immunoglobulin A vasculitis (IgAV)\u2010gastrointestinal (GI) tract involvement and to evaluate the outcomes of medical treatment and surgical intervention and the course of patients with intussusception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted in 157 patients under 18\u2009years of age who were followed up with the diagnosis of IgAV\u2010GI tract involvement between January 2015 and September 2022. The characteristics of the patients who developed intussusception were evaluated in detail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fifty\u2010seven patients with GI tract involvement were included in the study. The mean age of patients with IgAV\u2010GI tract involvement was 8.7\u00a0\u00b1\u20093.7\u2009years. The female\u2010to\u2010male ratio was 1:1.5. Intussusception was detected in 14 patients (8.9%). Two patients (14.3%) underwent surgery, and the remaining 12 patients (85.7%) had their medical therapy intensified. Patients with GI tract involvement were divided into two groups as with (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a0143) intussusception. There was a statistically significant difference between the groups in the time from the onset of the first symptom of IgAV to the onset of steroids (<jats:italic>P<\/jats:italic>\u00a0=\u20090.001). There were no statistically significant differences between the groups in age at onset of IgAV, gender distribution, erythrocyte sedimentation rate and C\u2010reactive protein levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The time from the onset of the first symptom of IgAV to the start of steroids is a risk factor for the development of intussusception in patients with IgAV\u2010GI tract involvement. In these patients, medical treatment usually reduces intussusception without the need for surgical intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16335","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T12:49:21Z","timestamp":1674564561000},"page":"505-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-3655","authenticated-orcid":false,"given":"Banu \u00c7","family":"Acar","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara 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Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-8347","authenticated-orcid":false,"given":"Tuba","family":"Kurt","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2235-4489","authenticated-orcid":false,"given":"Nil\u00fcfer","family":"Tekg\u00f6z","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara 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Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-2774","authenticated-orcid":false,"given":"Melike M","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3279-8435","authenticated-orcid":false,"given":"Merve C","family":"Polat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara 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