{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:09:33Z","timestamp":1778742573523,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T00:00:00Z","timestamp":1676332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012256","name":"Cerebral Palsy Alliance Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022099","name":"Cerebral Palsy Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aetiology of perinatal stroke is poorly understood. This study aimed to prospectively confirm the risk factors and identify any previously unknown variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective case\u2013control study was conducted in Australia. Univariate odds ratios (ORs), associated 95% confidence intervals (CIs) and multivariable logistic regression models fitted with backwards stepwise variable selection were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty perinatal stroke cases reported between 2017 and 2019 included 95% (57\/60) with multiple risk factors. Univariate analysis identified emergency caesarean section rather than NVD (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), low Apgar score (&lt;7) at 1, 5 and 10\u00a0min of age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), resuscitation at birth (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), abnormal cord blood gas (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), neonatal infection\/sepsis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), congenital heart disease (<jats:italic>P\u2009&lt;<\/jats:italic>\u00a00.01) and hypoglycaemia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) as significant risk factors. Multivariate analysis found smoking during pregnancy (OR: 1.48; 95% CI: 1.09\u20131.99), 1\u2010min Apgar score\u2009&lt;\u20097 (OR: 1.54; 95% CI: 1.15\u20132.08), 10\u2010min Apgar score\u2009&lt;\u20097 (OR: 1.26; 95% CI: 1.02\u20131.54) and hypoglycaemia (OR: 1.49; 95% CI: 1.07\u20132.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perinatal stroke is associated with multiple risk factors. Exposure to smoking, 10\u2010min Apgar score\u2009&lt;\u20097, neonatal infection and hypoglycaemia were independent risk factors. Emergency caesarean section, resuscitation at birth and abnormal cord blood gas were additional risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16372","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T12:50:32Z","timestamp":1676379032000},"page":"673-679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors for perinatal stroke in term infants: A case\u2013control study in Australia"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-6957","authenticated-orcid":false,"given":"Bithi","family":"Roy","sequence":"first","affiliation":[{"name":"The University of Sydney Children's Hospital Westmead Clinical School  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"The University of Notre Dame Australia  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel","family":"Webb","sequence":"additional","affiliation":[{"name":"Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Walker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"RPA Newborn Care Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Morgan","sequence":"additional","affiliation":[{"name":"The University of Sydney Children's Hospital Westmead Clinical School  Sydney New South Wales Australia"},{"name":"Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Badawi","sequence":"additional","affiliation":[{"name":"The University of Sydney Children's Hospital Westmead Clinical School  Sydney New South Wales Australia"},{"name":"Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Grace Centre for Newborn Intensive Care The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iona","family":"Novak","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Cerebral Palsy Alliance Research Institute, Discipline of Child and Adolescent Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.01.016"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317706600"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105735"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2007.04.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300973"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.05.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.642181"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13337"},{"key":"e_1_2_7_10_1","article-title":"Australian Paediatric Surveillance Unit (APSU) annual surveillance report 2020","volume":"2021","author":"Teutsch SM","year":"2018","journal-title":"Commun. 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