{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:34Z","timestamp":1792471114605,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Oral food challenges (OFC) are an important tool in the assessment of food allergy. We sought to identify factors available at initial assessment visit which were associated with successful outcome or challenge failure in Australian children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of all paediatric patients who underwent OFC in our allergy service over a 5\u2010year period. Clinical data comprising patient demographics, co\u2010morbidities, skin prick test (SPT) results, nature of previous reactions, elapsed time since previous reactions and outcome at OFC were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and fifty\u2010six OFCs were conducted, with 56 cases (12.3%) resulting in a reaction. Likelihood of reaction at OFC was significantly increased for patients with atopic dermatitis (odds ratio 1.99). When stratified by food substance, atopic dermatitis had the strongest association with reaction within the peanut group (odds ratio 3.2), and no association was demonstrated for soy or prawn. Increasing SPT wheal size (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and previous history of anaphylaxis to the challenge food (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) correlated with failure at OFC. A low\u2010risk group was identified, of patients with no clear history of prior reaction to the challenge food, and SPT result &lt;3\u2009mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Factors identified at assessment visit which correlated with reaction at OFC are atopic dermatitis, prior history of anaphylaxis, and increasing SPT wheal size. Domiciliary OFC could be considered in a select low\u2010risk group of patients undergoing food challenge. This study was performed at a single centre with limited sample size, further large\u2010scale and multicentre study verification of our data will provide more accurate representation of the Australian demographic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16398","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T06:29:08Z","timestamp":1680589748000},"page":"822-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oral food challenge outcomes in children and adolescents in a tertiary centre: A 5\u2010year experience"],"prefix":"10.1111","volume":"59","author":[{"given":"Joshua G","family":"Jacob","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergy Royal North Shore Hospital Sydney New South Wales Australia"},{"name":"School of Medicine The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suran L","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Royal North Shore Hospital Sydney New South Wales Australia"},{"name":"School of Medicine The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Nickolls","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Royal North Shore Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamma","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Royal North Shore Hospital Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.05.041"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50604"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.07.028"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.05.037"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","DOI":"10.1177\/0046958020910305","article-title":"Waiting time as an indicator for health services under strain: A narrative review","volume":"57","author":"McIntyre D","year":"2020","journal-title":"Inquiry"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.625796"},{"key":"e_1_2_6_9_1","first-page":"24","article-title":"Predictive values for food challenge\u2010induced severe reactions: Development of a simple food challenge score","volume":"14","author":"Cianferoni A","year":"2012","journal-title":"Isr. Med. Assoc. J."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-017-0215-8"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v49i3.103"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.05.013"},{"key":"e_1_2_6_13_1","unstructured":"ASCIA.Position Paper \u2013 Oral Food Allergen Challenges. Balgowlah NSW: Australasian Society of Clinical Immunology and Allergy;2022. Available from:https:\/\/www.allergy.org.au\/hp\/papers\/ascia-position-paper-food-allergen-challenges[accessed 4 July 2022]."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12957"},{"key":"e_1_2_6_16_1","unstructured":"ASCIA.Skin Prick Testing Guide for Diagnosis of Allergic Disease. Balgowlah NSW:Australasian Society of Clinical Immunology and Allergy;2020. Available from:https:\/\/www.allergy.org.au\/hp\/papers\/skin-prick-testing[accessed 12 December 2022]."},{"key":"e_1_2_6_17_1","unstructured":"ASCIA.ASCIA Guidelines \u2013 Acute Management of Anaphylaxis. Balgowlah NSW: Australasian Society of Clinical Immunology and Allergy;2021. Available from:https:\/\/www.allergy.org.au\/hp\/papers\/acute-management-of-anaphylaxis-guidelines[accessed 12 December 2022]."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13443"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.04.020"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14154"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.037"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12302"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.04.009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.08.060"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14009"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.12.003"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13871"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T17:13:58Z","timestamp":1729185238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,3]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jpc.16398"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16398","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,3]]},"assertion":[{"value":"2022-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}