{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:43:37Z","timestamp":1775889817731,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Actinomycosis is a rare subacute to chronic granulomatous infection which can mimic other infectious or malignant diseases. This study examined the epidemiology and treatment outcome of actinomycosis in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study on children admitted for actinomycosis in a tertiary paediatric hospital in Singapore, from January 2004 to December 2020. Clinical profile, therapeutic interventions and outcomes were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 patients were identified; 7 were female. The median age at first presentation was 9.8\u2009years (range 4.7\u201315.7). The most common presenting symptom was fever (<jats:italic>n<\/jats:italic>\u2009=\u20096, 60%), followed by facial or neck swelling (<jats:italic>n<\/jats:italic>\u2009=\u20093, 30%) and ear pain (<jats:italic>n<\/jats:italic>\u2009=\u20093, 30%). Actinomycosis occurred predominantly in the orocervicofacial region (<jats:italic>n<\/jats:italic>\u2009=\u20096, 60%). Four patients (40%) had preceding dental infections in the form of dental caries or gingivitis. One patient had poorly controlled insulin\u2010dependent diabetes mellitus. Actinomycosis was confirmed via culture in four patients, histopathology in four patients and both methods in two patients. All except one patient (<jats:italic>n<\/jats:italic>\u2009=\u20099, 90%) underwent surgical procedures. All patients received ampicillin or amoxicillin\/clavulanate or other beta\u2010lactams, for a median duration of 6.5\u2009months (range 1.5\u201314). Complications included osteomyelitis (<jats:italic>n<\/jats:italic>\u2009=\u20094, 40%), mastoiditis (<jats:italic>n<\/jats:italic>\u2009=\u20092, 20%), brain abscess (<jats:italic>n<\/jats:italic>\u2009=\u20091, 10%) and recurrent neck abscess (<jats:italic>n<\/jats:italic>\u2009=\u20091, 10%). There was no mortality and all patients achieved complete resolution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paediatric actinomycosis was rare in our 16\u2010year review, but had a high complication rate. It can occur in immunocompetent patients, and dental infection was the predominant risk factor identified. Prognosis was excellent after surgical intervention and appropriate antimicrobial therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16400","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T09:59:36Z","timestamp":1680688776000},"page":"833-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Paediatric actinomycosis: A 16\u2010year, single\u2010institution retrospective review of cases"],"prefix":"10.1111","volume":"59","author":[{"given":"Siu\u2010Jun","family":"Chew","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-2898","authenticated-orcid":false,"given":"Kelly BB","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine KK Women's and Children's Hospital  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Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen D","family":"Nadua","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Department of Pediatric Medicine KK Women's and Children's Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010National University of Singapore Medical School  Singapore"},{"name":"Lee Kong Chian School of Medicine, Imperial College London Nanyang Technological University  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Qian","family":"Kam","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Department of Pediatric Medicine KK Women's and Children's Hospital  Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore"},{"name":"Duke\u2010National University of Singapore Medical School  Singapore"},{"name":"Lee Kong Chian School of Medicine, Imperial College London Nanyang Technological University  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry KK","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derrick WQ","family":"Lian","sequence":"additional","affiliation":[{"name":"Department of Pathology National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon YR","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Medicine KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-5008","authenticated-orcid":false,"given":"Natalie WH","family":"Tan","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Department of Pediatric Medicine KK Women's and 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