{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:48:40Z","timestamp":1767772120029,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to clarify the characteristics and their mortality\u2010related factors in very low birthweight infants with Down syndrome (DS) in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective case\u2013control study enrolled newborns with DS weighing &lt;1500\u2009g admitted to neonatal intensive care unit (NICU) of the perinatal centre registered with the Neonatal Research Network of Japan (NRNJ) database from 2008 to 2019. The clinical characteristics and their mortality\u2010related factors were compared among the Dead group (newborns with DS who died in the NICU), the Survival group (newborns with DS who were alive from the NICU) and the Control group (newborns without congenital or chromosomal condition).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 53\u2009656 newborns weighing &lt;1500\u2009g were registered in the NRNJ database for 12\u2009years. Of these, 310 (0.6%) were diagnosed with DS: 62 newborns in the Dead group, 248 in the Survival group and 49\u2009786 in the Control group without chromosomal condition. Logistic analysis revealed that there was a significant difference in the mortality\u2010related factors in congenital anomalies, pulmonary haemorrhage and persistent pulmonary hypertension of the newborn; the adjusted odds ratios were 8.6, 121 and 9.5, respectively. Newborns with DS weighing &lt;1000\u2009g showed the earliest death in the NICU on the Kaplan\u2013Meier survival curve (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mortality rate for newborns with DS weighing &lt;1500\u2009g was 20% (5% in the Control group). The mortality\u2010related factors were complications of congenital anomalies, pulmonary haemorrhage and persistent pulmonary hypertension of the newborn.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16418","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:14:07Z","timestamp":1682669647000},"page":"912-918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of newborns with Down syndrome with weight less than 1500\u2009g in the neonatal intensive care unit: A Japanese multicentre study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-1247","authenticated-orcid":false,"given":"Shuji","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Pediatrics of Kitasato University Hospital  Sagamihara\u2010shi Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Division of Neonatal Intensive Care Medicine Research and Development Center for New Medical Frontiers of Kitasato University Hospital  Sagamihara\u2010shi Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics of Kitasato University Hospital  Sagamihara\u2010shi Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayano","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics of Kitasato University Hospital  Sagamihara\u2010shi Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Ooka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics of Kitasato University Hospital  Sagamihara\u2010shi Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Neonatal Research Network, 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