{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:19:14Z","timestamp":1792811954589,"version":"4.5.0"},"reference-count":12,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,8]]},"abstract":"\n Aim<\/jats:title>\n Western Australian laboratory data demonstrated a decrease in human metapneumovirus (hMPV) detections through 2020 associated with SARS\u2010CoV\u20102\u2010related non\u2010pharmaceutical interventions (NPIs), followed by a subsequent surge in metropolitan region in mid\u20102021. We aimed to assess the impact of the surge in hMPV on paediatric hospital admissions and the contribution of changes in testing.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n All respiratory\u2010coded admissions of children aged <16\u2009years at a tertiary paediatric centre between 2017 and 2021 were matched with respiratory virus testing data. Patients were grouped by age at presentation and by ICD\u201010 AM codes into bronchiolitis, other acute lower respiratory infection (OALRI), wheeze and upper respiratory tract infection (URTI). For analysis, 2017\u20132019 was utilised as a baseline period.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n hMPV\u2010positive admissions in 2021 were more than 2.8 times baseline. The largest increase in incidence was observed in the 1\u20134\u2009years group (incidence rate ratio (IRR) 3.8; 95% confidence interval (CI): 2.5\u20135.9) and in OALRI clinical phenotype (IRR 2.8; 95% CI: 1.8\u20134.2). The proportion of respiratory\u2010coded admissions tested for hMPV in 2021 doubled (32\u201366.2%,\n P<\/jats:italic>\n \u2009<\u20090.001), with the greatest increase in wheeze (12\u201375% in 2021,\n P<\/jats:italic>\n \u2009<\u20090.001). hMPV test percentage positivity in 2021 was higher than in the baseline period (7.6% vs. 10.1% in 2021,\n P<\/jats:italic>\n \u2009=\u20090.004).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The absence and subsequent surge underline the susceptibility of hMPV to NPIs. Increased hMPV\u2010positive admissions in 2021 can be partially attributable to testing, but test\u2010positivity remained high, consistent with a genuine increase. Continued comprehensive testing will help ascertain true burden of hMPV respiratory diseases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jpc.16445","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T08:25:43Z","timestamp":1684830343000},"page":"987-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A surge in human metapneumovirus paediatric respiratory admissions in Western Australia following the reduction of\n SARS\u2010CoV\u20102<\/scp>\n non\u2010pharmaceutical interventions"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-7809","authenticated-orcid":false,"given":"David A","family":"Foley","sequence":"first","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-612X","authenticated-orcid":false,"given":"Daniel K","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara A","family":"Minney\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Shin","sequence":"additional","affiliation":[{"name":"Princeton University Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briony","family":"Hazelton","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hoeppner","sequence":"additional","affiliation":[{"name":"Emergency Department Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C","family":"Moore","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute University of Western Australia Perth Western Australia Australia"},{"name":"School of Population Health Curtin University Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Nicol","sequence":"additional","affiliation":[{"name":"Marshall Centre, Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisha","family":"Sikazwe","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Marshall Centre, Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith L","family":"Borland","sequence":"additional","affiliation":[{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"},{"name":"Emergency Department Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram","family":"Levy","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Marshall Centre, Biomedical Sciences University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris C","family":"Blyth","sequence":"additional","affiliation":[{"name":"Department of Microbiology PathWest Laboratory Medicine WA Perth Western Australia Australia"},{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute University of Western Australia Perth Western Australia Australia"},{"name":"School of Medicine University of Western Australia Perth Western Australia Australia"},{"name":"Department of Infectious Diseases Perth Children's Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(20)30393-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epidem.2016.05.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1475"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323375"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14102135"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.11.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003396"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.04.037"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2021.1887510"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12139"},{"key":"e_1_2_7_12_1","unstructured":"Australian Bureau of Statistics.Australian Demographic Statisitics.2022."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323375"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T18:11:53Z","timestamp":1692209513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jpc.16445"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16445","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2023-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}