{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:31:55Z","timestamp":1788013915656,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010847","name":"Coeliac Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Coeliac disease (CD) can remain undiagnosed due to absent\/atypical symptoms. We evaluated screening for CD in undifferentiated paediatric patients in the emergency department (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were all patients presenting to a children's hospital ED during the study period who had blood taken. Plasma remaining after routine care was tested for tissue transglutaminase IgA (tTG IgA) and deamidated gliadin IgG (DGP IgG) antibodies. Patients with positive results were counselled and offered confirmatory testing, then gastroenterology review if warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An initial positive result for either DGP IgG or tTG IgA was found in 4.2% (44\/1055). There was a normalisation of 76% (19\/25) of positive DGP IgG and 44% (4\/9) of tTG IgA results on repeat testing, which was not available in 27% (12\/44). The prevalence of biopsy\u2010confirmed CD was 0.7% (7\/1055), including two new diagnoses and five subjects with known CD. Three likely cases could not be confirmed. All confirmed and likely cases were &gt;10\u2009years old. In children &gt;10\u2009years old, the prevalence of either biopsy\u2010confirmed or likely CD was 3.3% (10\/302). A family history of CD, growth concerns, recurrent abdominal pain and lethargy were associated with persistence of positive tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Opportunistic testing for CD in ED requires further investigation as a CD screening strategy. Our results suggest optimal screening in this setting should be by initially testing for tTG IgA and total IgA in children &gt;10\u2009years old (minimising transiently positive tests). Transiently positive coeliac antibodies may also warrant further investigation as a predictor of future CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16446","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T11:00:10Z","timestamp":1685358010000},"page":"992-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Opportunistic coeliac disease screening in undifferentiated presentations to paediatric acute care"],"prefix":"10.1111","volume":"59","author":[{"given":"Karrnan","family":"Pathmanandavel","sequence":"first","affiliation":[{"name":"Department of Allergy and Immunology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3614-7085","authenticated-orcid":false,"given":"Michael","family":"Stormon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Nogajski","sequence":"additional","affiliation":[{"name":"Emergency Department The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology The Children's Hospital at Westmead  Sydney New South Wales Australia"},{"name":"Central Clinical School, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31796-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002497"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1380-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000751"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00056"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.059"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002465"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.03.049"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000737"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31818c52cc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00243-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328133f0c1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.183"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001681"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000992"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-019-4407-4"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-021-03974-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15182"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.06.037"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1305"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04054.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-2016-0"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.77"},{"key":"e_1_2_7_26_1","unstructured":"WilsonJMG JungnerG; World Health Organization.Principles and Practice of Screening for Disease. 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