{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:37:56Z","timestamp":1747186676854,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To characterise parathyroid hormone (PTH) concentrations in infants at high risk for metabolic bone disease, in order to assist clinical decisions around the use of PTH for screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants born under 28\u2009weeks' postmenstrual age or with birthweight under 1.5\u2009kg in a tertiary neonatal unit in the UK were included. Clinical guidance was to assess PTH concentration in the first 3\u2009weeks after birth. Clinical information was extracted from prospective records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four infants had mean birth gestation of 26\u2009weeks and birthweight of 882\u2009g. Median PTH (sent on median day 18 of life) was 9.2\u2009pmol\/L (interquartile range 5.3\u201317\u2009pmol\/L). Sixty\u2010seven per cent of infants had a PTH greater than 7\u2009pmol\/L. For 22% of the infants, raised PTH was not accompanied by abnormal phosphate or alkaline phosphatase. Eighty\u2010nine per cent of infants tested were insufficient or deficient for 25\u2010hydroxyvitamin D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Universal screening highlights the high frequency of high PTH in this high\u2010risk population, implying a need for calcium supplementation. A considerable number of infants would not be identified as showing potential signs of metabolic bone disease if the assessment excludes the use of PTH. The high level of 25\u2010hydroxyvitamin D deficiency may be a confounder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16470","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T07:59:17Z","timestamp":1691395157000},"page":"1140-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterisation of parathyroid hormone concentration in extremely preterm or very low birthweight infants in routine clinical screening for metabolic bone disease: A service evaluation cohort study"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-3533","authenticated-orcid":false,"given":"Ilana","family":"Levene","sequence":"first","affiliation":[{"name":"Newborn Care Unit John Radcliffe Hospital  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amraj","family":"Dhami","sequence":"additional","affiliation":[{"name":"Newborn Care Unit John Radcliffe Hospital  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Moreno","sequence":"additional","affiliation":[{"name":"Pharmacy Department John Radcliffe Hospital  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Shine","sequence":"additional","affiliation":[{"name":"Biochemistry Department John Radcliffe Hospital  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amish","family":"Chinoy","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Royal Manchester Children's Hospital  Manchester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Padidela","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology Royal Manchester Children's Hospital  Manchester United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Molnar","sequence":"additional","affiliation":[{"name":"Newborn Care Unit John Radcliffe Hospital  Oxford United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2014.06.004"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-316330"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15654"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90810-R"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.97"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1450858"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-47"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.546544"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101086"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0420"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0098-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2010.01901.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2000.tb00395.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1602419"},{"key":"e_1_2_8_17_1","unstructured":"British Association of Perinatal Medicine. 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