{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:22:47Z","timestamp":1790022167926,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Australian and New Zealand guidelines recommend that live vaccines be postponed for 11\u2009months after treatment of Kawasaki disease (KD) with intravenous immunoglobulin (IVIG). We aimed to describe patterns of live\u2010vaccine administration after KD treatment, focusing on the measles\u2013mumps\u2013rubella\/measles\u2013mumps\u2013rubella\u2013varicella (MMR\/MMRV) vaccines, and to compare real\u2010world practice with current recommendations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We combined data from inpatient Electronic Health Records and the Australian Immunisation Register for all children who received IVIG for the treatment of KD under the age of 5\u2009years at two Australian tertiary children's hospitals over a 12\u2010year period. Children who received IVIG &lt;11\u2009months before a scheduled MMR\/MMRV were deemed \u2018at risk\u2019 of breaching the guidelines, and those whose subsequent vaccination occurred &lt;11\u2009months after the IVIG were deemed to have \u2018breached\u2019 the guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of those at risk, three\u2010quarters (76%) breached the guidelines for their first MMR\/MMRV. Findings were similar (50%\u201380%) for the second MMR\/MMRV dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The majority of Australian children treated for KD with IVIG may not be optimally protected by MMRV vaccination. Immunisation systems should address this avoidable risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16484","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:58:49Z","timestamp":1693817929000},"page":"1217-1222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Live vaccines following intravenous immunoglobulin for Kawasaki disease: Are we vaccinating appropriately?"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-1318","authenticated-orcid":false,"given":"Cassandra","family":"Cardenas\u2010Brown","sequence":"first","affiliation":[{"name":"Department of Rheumatology The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2467-8708","authenticated-orcid":false,"given":"Ryan D","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"},{"name":"Discipline of Child and Adolescent Health The University of Sydney Faculty of Medicine and Health  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Buttery","sequence":"additional","affiliation":[{"name":"Infection and Immunity Theme Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Melbourne Medical School, Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Centre for Health Analytics, Melbourne Children's Campus  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-6000","authenticated-orcid":false,"given":"Philip N","family":"Britton","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health The University of Sydney Faculty of Medicine and Health  Sydney New South Wales Australia"},{"name":"National Centre for Immunisation Research &amp; Surveillance  Sydney New South Wales Australia"},{"name":"Department of Infectious Diseases The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"},{"name":"Discipline of Child and Adolescent Health The University of Sydney Faculty of Medicine and Health  Sydney New South Wales Australia"},{"name":"National Centre for Immunisation Research &amp; Surveillance  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-3713","authenticated-orcid":false,"given":"Davinder","family":"Singh\u2010Grewal","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The Sydney Children's Hospitals Network Randwick and Westmead  Sydney New South Wales Australia"},{"name":"Discipline of Child and Adolescent Health The University of Sydney Faculty of Medicine and Health  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales Faculty of Medicine  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-4302","authenticated-orcid":false,"given":"David","family":"Burgner","sequence":"additional","affiliation":[{"name":"Infection and Immunity Theme Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Melbourne Medical School, Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000484"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key344"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ped.12317"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.032"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090232"},{"key":"e_1_2_7_7_1","unstructured":"National Blood Authority (Australia).Criteria for the clinical use of intravenous immunoglobulin in Australia.2012."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2016.1128329"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-022-00594-6"},{"key":"e_1_2_7_10_1","volume-title":"Australian Immunisation Handbook","author":"Australian Technical Advisory Group on Immunisation (ATAGI)","year":"2022"},{"key":"e_1_2_7_11_1","volume-title":"Immunisation Handbook 2020","year":"2020"},{"key":"e_1_2_7_12_1","unstructured":"Public Health Agency of Canada.Blood products human immunoglobulin and timing of immunization.Canadian Immunization Guide.2021. 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Los Angeles California;1992."},{"key":"e_1_2_7_17_1","doi-asserted-by":"crossref","unstructured":"MasonWH SchneiderTL TakahashiM.Duration of passively acquired measles antibody and response to live virus vaccination allowing gamma globulin therapy for Kawasaki syndrome. Wailea Hawaii;1991.","DOI":"10.1016\/S1058-9813(06)80067-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(06)80114-9"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-003-1335-3"},{"key":"e_1_2_7_20_1","first-page":"1929","article-title":"Intravenous gamma\u2010globulin therapy and vaccination","volume":"26","author":"Sonobe T","year":"1994","journal-title":"Shoni\u2010Naika"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.01.045"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.07.097"},{"key":"e_1_2_7_23_1","unstructured":"Services Australia.Australian Immunisation Register. 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