{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:08:13Z","timestamp":1778810893393,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Langerhans cell histiocytosis (LCH) is a rare proliferative disorder characterised as an inflammatory myeloid neoplasia. Endocrine manifestations of LCH, particularly central diabetes insipidus (CDI), have been described from the 1940s, through case studies and small cohort analyses. There are limited Australian paediatric data described in recent literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To document the incidence of endocrine features in paediatric patients with LCH, treated at a tertiary paediatric centre in Victoria, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective chart review of electronic medical records and oncology database of patients with LCH managed at a tertiary paediatric centre. Patients were excluded if a biopsy did not suggest LCH or if records were incomplete.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010one patients were identified and 141 records of patients diagnosed with LCH over the last 30\u2009years were assessed for endocrinopathies, from diagnosis to last documented follow\u2010up. Mean age at diagnosis was 5\u2009years 8\u2009months. Of these, 15% (<jats:italic>n<\/jats:italic>\u2009=\u200921) had CDI, 7% had growth hormone deficiency (GHD) (<jats:italic>n<\/jats:italic>\u2009=\u200910) and 8% (<jats:italic>n<\/jats:italic>\u2009=\u200911) had more than one endocrinopathy noted during follow\u2010up. Forty percent (<jats:italic>n<\/jats:italic>\u2009=\u200957) were pre\u2010pubertal at the time of audit or upon discharge from tertiary services.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ongoing pituitary assessment, in addition to CDI, is required to detect evolving deficiencies of GHD and gonadotropins as these can be subtle, late or missed. Close follow\u2010up of growth and progression through puberty, even if discharged from tertiary care, is essential.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16521","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T06:35:01Z","timestamp":1701326101000},"page":"24-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Endocrine features of<scp>Langerhans<\/scp>cell histiocytosis in paediatric patients: A 30\u2010year review"],"prefix":"10.1111","volume":"60","author":[{"given":"Ashley","family":"Alexander","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Zacharin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27454"},{"key":"e_1_2_8_3_1","first-page":"489","article-title":"The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder","volume":"8","author":"Papadopoulou M","year":"2018","journal-title":"Mol. 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