{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:38:06Z","timestamp":1747186686046,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Typhoid is endemic in many low\u2010income countries, including in Papua New Guinea. This study aimed to describe the burden and clinical features of typhoid in children in a provincial hospital, to describe environmental conditions that lead to typhoid, and to document the antibiotic sensitivity of <jats:italic>Salmonella spp<\/jats:italic>. in the Eastern Highlands Province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A combined retrospective and prospective study of children admitted to with clinical features of typhoid to the Goroka Hospital throughout 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 98 children, of which 54% were female. The median age was 8 (IQR 5\u201310.6) years. Over 60% of the patients were from Goroka District, the peri\u2010urban area encompassing the town and surrounds. Ninety\u2010four percent (92) of the patients used a pit latrine as a toilet and only 28% had access to treated water. Neuropsychiatric symptoms were common (60%), as was leukopenia (48%), thrombocytopenia (52%) and anaemia (42%). Thirty\u2010seven patients had positive blood cultures for <jats:italic>Salmonella typhi<\/jats:italic>; all isolates were sensitive to third\u2010generation cephalosporins, pefloxacin, ampicillin, trimethoprim and sulfamethoxazole, and only 54% sensitive to chloramphenicol. The median duration of hospitalisation was 6\u2009days (IQR). There were no deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prompt public health actions are needed to reduce the burden of typhoid infection in the Papua New Guinea. The conjugate typhoid vaccine should be considered in the highlands region, where typhoid is most endemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16553","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T11:19:18Z","timestamp":1714043958000},"page":"188-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Typhoid fever in children in <scp>Goroka, Papua New Guinea<\/scp>"],"prefix":"10.1111","volume":"60","author":[{"given":"Whitney Ato","family":"Ruape","sequence":"first","affiliation":[{"name":"Goroka Provincial Hospital  Goroka Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casparia","family":"Mond","sequence":"additional","affiliation":[{"name":"Goroka Provincial Hospital  Goroka Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watson","family":"Toroi","sequence":"additional","affiliation":[{"name":"Goroka Provincial Hospital  Goroka Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Becky","family":"Max","sequence":"additional","affiliation":[{"name":"Goroka Provincial Hospital  Goroka Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Chanoan","sequence":"additional","affiliation":[{"name":"Goroka Provincial Hospital  Goroka Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-1416","authenticated-orcid":false,"given":"Trevor","family":"Duke","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Sciences University of PNG  Port Moresby Papua New Guinea"},{"name":"Department of Paediatrics and Intensive Care Unit University of Melbourne, Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30685-6"},{"key":"e_1_2_6_3_1","unstructured":"World Health Organization.Typhoid.2023. 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