{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:13Z","timestamp":1787015713238,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014555","name":"Murdoch Children's Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We aimed to investigate the frequency of vitamin C deficiency scurvy in the Australian paediatric context, describe cohorts at risk, and identify factors associated with development of symptoms in children with vitamin C deficiency. We also aimed to propose a management guideline for children with features of scurvy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective study was done at a tertiary paediatric hospital in Australia over a three\u2010year period, from August 2019 to July 2022. Children from birth to 18\u2009years old, whose vitamin C levels were low (&lt;23\u2009\u03bcmol\/L), were included. Data extracted from hospital medical records included demographics, weight, co\u2010morbidities, eating disorder diagnoses, clinical features, investigations and treatment. Descriptive statistics and risk statistics were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In a cohort of 887 patients who had their vitamin C levels checked, we identified 272 (31%) who had a vitamin C level &lt;23\u2009\u03bcmol\/L. Of these, 13 (5%) were symptomatic of vitamin C deficiency and 19 (7%) may have been symptomatic. In patients with vitamin C deficiency, 248 (91%) had comorbidities, neurodevelopmental disorders being most common, and 176 (65%) had restricted eating. When the asymptomatic and symptomatic groups were compared, in the symptomatic group, there was a significantly lower vitamin C level and disordered eating related to autism spectrum disorders was more common.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In order to avoid delayed diagnoses and unnecessary investigations, clinicians should be familiar with symptoms of scurvy and perform a dietary assessment, vitamin C assay, and commence empiric vitamin C supplementation where appropriate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.16594","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:59:36Z","timestamp":1718960376000},"page":"409-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Scurvy and vitamin\n                    <scp>C<\/scp>\n                    deficiency in an\n                    <scp>Australian<\/scp>\n                    tertiary children's hospital"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-9918","authenticated-orcid":false,"given":"Carolyn","family":"van Heerden","sequence":"first","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-957X","authenticated-orcid":false,"given":"Daryl R","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"},{"name":"Centre for Health Analytics  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McNab","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Burgess","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashleigh","family":"Russell","sequence":"additional","affiliation":[{"name":"The University\u00a0of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Wang","sequence":"additional","affiliation":[{"name":"The University\u00a0of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freya","family":"Bleathman","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Maharaj","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Zhang","sequence":"additional","affiliation":[{"name":"The University\u00a0of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marley","family":"Easterbrook","sequence":"additional","affiliation":[{"name":"The University\u00a0of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Papadopulos","sequence":"additional","affiliation":[{"name":"The University\u00a0of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila F","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of General Medicine The Royal Children's Hospital  Melbourne Victoria Australia"},{"name":"Department of Paediatrics The University of Melbourne  Melbourne Victoria Australia"},{"name":"Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000003563"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200001000-00007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare9060741"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.03.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/adj.12889"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0000000000000782"},{"key":"e_1_2_6_8_1","first-page":"536","article-title":"A rare case of scurvy in an otherwise healthy child: Diagnosis through oral signs","volume":"32","author":"Bacci C","year":"2010","journal-title":"Pediatr. 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