{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:20:10Z","timestamp":1792466410900,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Stricture formation is the most common remote complication of caustic ingestion. The aim of this study was evaluation of the efficacy of early topical endoscopic application of mitomycin C (MMC) in prevention of stricture formation after corrosive ingestion in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 78 children with a history of caustic ingestion within 48\u2009h in a prospective, randomised\u2010controlled study. Only 61 children completed the study and were classified into two groups: group A and B. After initial stabilisation, patients in group A (<jats:italic>n<\/jats:italic>\u2009=\u200930) received topical application of MMC within the initial 48\u2009h while patients in group B (<jats:italic>n<\/jats:italic>\u2009=\u200931) only received conventional management. Follow\u2010up endoscopic dilatation was done every 2\u2009weeks to patients in either group until no need for further dilatation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The barium study, which was done on the third week, revealed that all the patients (100%) on conservative management (group B) had strictures while only nine patients (30%) in group A had strictures (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The median number of dilatations required for patients in group B was 26 (min.\u2009=\u200923 and max.\u2009=\u200932) while in group A, it was 0 (min.\u2009=\u20090 and max.\u2009=\u20097) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The success of early MMC application was complete response in 26 patients (86.7%), partial response in 3 patients (10%) and no response in 1 patient (3.3%). On the other side, conventional therapy with endoscopic dilatation achieved complete response in 11 patients (35.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early topical MMC application proved its efficacy and safety in prevention of scar and stricture formation in children following caustic ingestion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16595","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:40:47Z","timestamp":1718365247000},"page":"402-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early topical mitomycin\u2010<scp>C<\/scp> prevents stricture formation in children with caustic ingestion"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-3529","authenticated-orcid":false,"given":"Happy","family":"Sawires","sequence":"first","affiliation":[{"name":"Pediatric Department Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4763-7733","authenticated-orcid":false,"given":"Ayman","family":"Aeskander","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Department Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Pediatric Department Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0616-1737","authenticated-orcid":false,"given":"Mohamed","family":"Marei","sequence":"additional","affiliation":[{"name":"Ministry of Health  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-4019","authenticated-orcid":false,"given":"Sara","family":"Tarek","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology Department Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100629"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810769"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v8.i2.90"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000295"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12092"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310283291803"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(91)70678-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(03)00105-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802c6e45"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.08.002"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.04.014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1311695"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2016.06.024"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0004-2803.202100000-38"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000462"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1357754"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.4.401"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S25611"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.02.011"},{"key":"e_1_2_5_21_1","first-page":"248","article-title":"Topical mitomycin C versus intralesional triamcinolone in the management of esophageal stricture due to caustic ingestion","volume":"80","author":"Mendez\u2010Nieto CM","year":"2015","journal-title":"Rev. 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