{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:11:06Z","timestamp":1777464666593,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease characterised by recurrent episodes of fever and polyserositis. Sacroiliac joint involvement is rare in FMF patients. The purpose of this study was to evaluate the demographic, clinical, laboratory and imaging findings of patients with FMF who developed sacroiliitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The files of paediatric patients aged 0\u201318\u2009years who were followed up with a diagnosis of FMF were retrospectively reviewed. FMF patients with evidence of sacroiliitis on magnetic resonance imaging (MRI) were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1062 FMF patients, 22 (12 males; median age 8.5) (2.1%) of them were found to have sacroiliitis. FMF was diagnosed before sacroiliitis in nine (40.9%) patients and after in 13 (59.1%) patients. The most common symptom in patients with sacroiliitis was low back pain (<jats:italic>n<\/jats:italic>\u2009=\u200921, 95.5%). In <jats:italic>MEFV<\/jats:italic> gene analysis, M694V was found in 16 (72.7%) patients and was the most common mutation. MRI showed evidence of sacroiliitis in all patients. All patients were using colchicine. Patients with FMF\u2010associated sacroiliitis, remission was achieved with non\u2010steroidal anti\u2010inflammatory drugs in 12 (54.5%), conventional disease\u2010modifying antirheumatic drugs in six (27.3%) and tumour necrosis factor inhibitor treatment in four (31.8%). Four (31.8%) patients experienced sacroiliitis when colchicine incompatible and four (31.8%) patients experienced sacroiliitis while using biologic agents for colchicine\u2010resistant FMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FMF\u2010associated sacroiliitis should be considered especially in patients with M694V mutation if they have symptoms such as low back pain. Colchicine\u2010resistant FMF patients should be evaluated for sacroiliitis symptoms at each visit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16623","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T11:19:37Z","timestamp":1721906377000},"page":"511-515","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sacroiliitis in familial Mediterranean fever: A rare joint involvement of the disease"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-8342","authenticated-orcid":false,"given":"Emine","family":"\u00d6z\u00e7elik","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0129-4410","authenticated-orcid":false,"given":"Elif","family":"\u00c7elikel","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5446-667X","authenticated-orcid":false,"given":"Zahide Ekici","family":"Tekin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-2603","authenticated-orcid":false,"given":"Vildan","family":"G\u00fcng\u00f6rer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-1980","authenticated-orcid":false,"given":"C\u00fcneyt","family":"Karag\u00f6l","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8012-2774","authenticated-orcid":false,"given":"Melike Mehve\u015f","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0403-151X","authenticated-orcid":false,"given":"Nimet","family":"\u00d6ner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3279-8435","authenticated-orcid":false,"given":"Merve Cansu","family":"Polat","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-9225","authenticated-orcid":false,"given":"Didem","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7942-3714","authenticated-orcid":false,"given":"Mehve\u015f I\u015f\u0131klar","family":"Ekici","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-8708","authenticated-orcid":false,"given":"Yasemin U\u011fur","family":"Es","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-3655","authenticated-orcid":false,"given":"Banu \u00c7elikel","family":"Acar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics University of Health Sciences, Ankara Bilkent City Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-022-06082-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119584"},{"key":"e_1_2_6_4_1","first-page":"859","article-title":"Arthritis as the sole episodic manifestation of familial Mediterranean fever","volume":"32","author":"Lidar M","year":"2005","journal-title":"J. Rheumatol."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S149494"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2020.33.4.294"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/clinpract14010009"},{"key":"e_1_2_6_8_1","first-page":"438","article-title":"The musculoskeletal system manifestations in children with familial Mediterranean fever","volume":"7","author":"Demir F","year":"2020","journal-title":"North. Clin. Istanb."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken509"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-011-0191-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1708147"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s42358-021-00188-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.805919"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04443-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2020.1724450"},{"key":"e_1_2_6_16_1","first-page":"124","article-title":"Comparison of patients with familial Mediterranean fever accompanied with sacroiliitis and patients with juvenile spondyloarthropathy","volume":"35","author":"S\u00f6nmez HE","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa863"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1201-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000002002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxad050"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223296"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208690"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31823682f5"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T03:40:24Z","timestamp":1729050024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jpc.16623"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16623","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}