{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:46:40Z","timestamp":1783478800627,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the suitability of serum osteocalcin (OC) as a marker to distinguish between rapidly and non\u2010rapidly progressive central precocious puberty (RP\u2010CPP and NRP\u2010CPP), as well as its potential to assess growth rates following treatment with gonadotropin\u2010releasing hormone agonist (GnRHa).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum levels of OC were measured using enzyme\u2010linked immunosorbent assays in girls diagnosed with either RP\u2010CPP or NRP\u2010CPP as well as in normal control subjects. Receiver operating characteristic (ROC) curve analysis was performed to determine the cut\u2010off value for OC. Multivariate linear regression analysis was used to analyse the main influencing factors associated with OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum OC levels were higher in the CPP girls when compared to normal controls (110.76\u2009\u00b1\u200943.69 vs 55.97\u2009\u00b1\u200920.96\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The level in the RP\u2010CPP group was higher than the NRP\u2010CPP group (153.28\u2009\u00b1\u200933.89 vs 88.33\u2009\u00b1\u200929.26\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The cut\u2010off value of OC levels for distinguishing between RP\u2010CPP and NRP\u2010CPP was 107.05\u2009ng\/mL, the sensitivity was 94.7% and the specificity was 77.8%, which was superior to using the basal luteinising hormone (B\u2010LH) levels, and the area under ROC curve (AUC) were 0.933 versus 0.695, respectively. Following 1\u20132\u2009years of treatment with GnRHa for girls with CPP, both OC levels and the growth rates decreased to pre\u2010pubertal values. B\u2010LH levels, bone age and body weight were also significant factors, which affected OC levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum OC levels may be a useful marker for distinguishing RP\u2010CPP from NRP\u2010CPP. In addition, it was also found to be a useful predictor for growth rate during GnRHa treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16632","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T02:48:55Z","timestamp":1725072535000},"page":"593-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Osteocalcin: A potential marker to identify and monitor girls with rapidly progressive central precocious puberty"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5615-3151","authenticated-orcid":false,"given":"Wei","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-9980","authenticated-orcid":false,"given":"Suren R","family":"Sooranna","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London, Chelsea and Westminster Hospital  London United Kingdom"},{"name":"Life Science and Clinical Research Center Youjiang Medical University for Nationalities  Baise China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-7040","authenticated-orcid":false,"given":"Dan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi Zhuang Autonomous Region China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2022.2022-12-11"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.839895"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0577"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05174-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207513"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2020.100752"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0323"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27767"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171320"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI153752"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65952"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.04.036"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2485-4"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.610227"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.245.239"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0243"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922814541807"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-14-0010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2019\/e1205"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2019.60.12.1174"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5363-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041568"},{"key":"e_1_2_10_25_1","first-page":"311","article-title":"Relationship between body mass index and sexual development in Chinese children","volume":"60","author":"Xu XQ","year":"2022","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2244062.031"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0246-y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1515\/IJAMH.2002.14.3.235"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-017-0184-y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3428-z"}],"container-title":["Journal of Paediatrics and Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jpc.16632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T03:41:10Z","timestamp":1729050070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jpc.16632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,30]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jpc.16632"],"URL":"https:\/\/doi.org\/10.1111\/jpc.16632","archive":["Portico"],"relation":{},"ISSN":["1034-4810","1440-1754"],"issn-type":[{"value":"1034-4810","type":"print"},{"value":"1440-1754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,30]]},"assertion":[{"value":"2024-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}