{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:09:34Z","timestamp":1792624174806,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022099","name":"Cerebral Palsy Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Perinatal stroke is one of the main causes of hemiplegia and seizure disorder. This study aimed to analyse the clinical characteristics and outcomes of perinatal stroke in a cohort of Australian children for its early detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A population\u2010based prospective longitudinal study on perinatal stroke up to 2\u2009years of age, was conducted from 2017 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010seven children with perinatal stroke included 79% (69\/87) acute and 21% (18\/87) presumed perinatal stroke. Seventy\u2010four per cent (51\/69) acute symptomatic perinatal strokes presented in the first 3\u2009days of life and 78% (14\/18) presumed perinatal strokes presented by 6\u2009months of age. 62% had an arterial stroke, 29% had a venous stroke and 5% had a combined arterial and venous stroke. Unexpectedly, 35% (24\/69) acute symptomatic perinatal stroke had only respiratory symptoms and 50% (9\/18) presumed perinatal stroke were asymptomatic. The incidence of cerebral palsy was 29% (20\/69) with acute symptomatic perinatal stroke and 72% (13\/18) with presumed perinatal stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The first week of a child's life is the most critical period in terms of lifelong disability from perinatal stroke. Recognising diverse clinical presentations will ensure early diagnosis and timely intervention treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16640","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T10:24:01Z","timestamp":1724149441000},"page":"586-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics and outcomes of perinatal stroke in Australia: Population\u2010based longitudinal study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2741-6957","authenticated-orcid":false,"given":"Bithi","family":"Roy","sequence":"first","affiliation":[{"name":"Children's Hospital Westmead Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"The Mater Hospital  Sydney New South Wales Australia"},{"name":"The University of Notre Dame Australia  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annabel","family":"Webb","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health Cerebral Palsy Alliance Research Institute, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Walker","sequence":"additional","affiliation":[{"name":"RPA Newborn Care, Sydney Local Health District  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Morgan","sequence":"additional","affiliation":[{"name":"Children's Hospital Westmead Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Child and Adolescent Health Cerebral Palsy Alliance Research Institute, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Badawi","sequence":"additional","affiliation":[{"name":"Children's Hospital Westmead Clinical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"Discipline of Child and Adolescent Health Cerebral Palsy Alliance Research Institute, The University of Sydney  Sydney New South Wales Australia"},{"name":"Grace Centre for Newborn Intensive Care, The Children's Hospital at Westmead  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Novak","sequence":"additional","affiliation":[{"name":"Discipline of Child and Adolescent Health Cerebral Palsy Alliance Research Institute, The University of Sydney  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Knowledgebase A.Perinatal Period: Australian Institute of Health and Welfare 2015\u20132023; 2005. 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