{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:28:11Z","timestamp":1792124891123,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Sepsis is a common cause of neonatal mortality and morbidity. Though antibiotics are the mainstay of treatment in culture\u2010positive neonatal sepsis, the dilemma persists for the optimum duration of antimicrobial therapy. The present study aimed to evaluate the efficacy of short\u2010course antibiotics for uncomplicated culture\u2010positive neonatal sepsis. This systematic review and meta\u2010analysis (PROSPERO: CRD42023444899) identified, appraised, and synthesised the available evidence from randomised and quasi\u2010randomised controlled trials related to the efficacy of short\u2010course (7\u201310\u2009days) versus standard\u2010course (14\u2009days) antibiotics for uncomplicated culture\u2010positive neonatal sepsis on the rate of treatment failure, mortality, duration of hospitalisation, morbidities including antibiotics\u2010related adverse events, long\u2010term neurodevelopmental outcomes and cost analysis. Data were pooled using RevMan 5.4 software. Certainty of evidence (COE) for predefined outcomes was analysed by GRADE. Available evidence showed no significant difference in the rate of treatment failure between 7\u2010 to 10\u2010day versus 14\u2010day antibiotics courses [risk ratio (95% confidence interval, CI), 2.45 (0.93\u20136.47), <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, six studies, <jats:italic>n<\/jats:italic>\u2009=\u2009573, very low COE]. No incidence of death was reported in either treatment arm in the two included studies. Duration of hospitalisation was significantly shorter with the short\u2010course antibiotics arm compared to standard\u2010course [mean difference (95% CI), \u22123.88 (\u22124.22 to \u22123.54) days, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%, five studies, <jats:italic>n<\/jats:italic>\u2009=\u2009507, low COE]. Morbidities reported in the three studies were similar. Other outcomes were not reported. To conclude the evidence is very uncertain about the effect of short\u2010course antibiotic regimen, compared to a standard\u2010course, on the treatment failure rate in uncomplicated culture\u2010positive neonatal sepsis. Adequately powered trials with outcomes including death and long\u2010term neurodevelopmental impairment are needed.<\/jats:p>","DOI":"10.1111\/jpc.16647","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:46:27Z","timestamp":1723808787000},"page":"630-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of short\u2010course antibiotics for culture\u2010positive neonatal sepsis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"60","author":[{"given":"Poonam","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Neonatology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-6181","authenticated-orcid":false,"given":"Mayank","family":"Priyadarshi","sequence":"additional","affiliation":[{"name":"Department of Neonatology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Chaurasia","sequence":"additional","affiliation":[{"name":"Department of Neonatology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-4849","authenticated-orcid":false,"given":"Sriparna","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Neonatology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(21)00311-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01749-3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-10-39"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2020-320664"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare7010028"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-1248"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-3423"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.033"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-2677"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01584"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3407"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-308255"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq107"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.894005"},{"key":"e_1_2_5_16_1","unstructured":"Available from:https:\/\/cdn\u2010links.lww.com\/permalink\/inf\/e\/inf_2022_01_05_stritzke_pidj\u2010221\u20101056_sdc1.pdf[accessed 16 August 2023]."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199001000-00002"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fml054"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmq012"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_5_21_1","unstructured":"HigginsJPT ThomasJ ChandlerJet al. eds.Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 [updated February 2022]. 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