{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T08:18:08Z","timestamp":1782634688626,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to detect subclinical cardiac impairment in children with ulcerative colitis (UC) and test the association between absolute monocytic count (AMC) and lymphocyte\u2010to\u2010monocyte ratio (LMR) with disease activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A group of children with UC and a comparable group as healthy controls were included. All children underwent history\u2010taking, clinical examination and blood testing for complete blood counts with white blood cell differentials, LMR and erythrocyte sedimentation rate (ESR). Disease severity was assessed using the Paediatric UC Activity Index score. We used echocardiography for tissue Doppler, M\u2010Mode, two\u2010dimensional and three\u2010dimensional (3D) speckle tracking echocardiography (STE) for left ventricular function assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty children were included, 20 with UC as cases, and 20 healthy controls. Disease activity was mild in 75% cases and moderate in 25% cases. Cases had significantly higher ESR than the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Among cases, positive correlations were observed between monocytic, and platelet counts with left ventricular end\u2010diastolic diameter (<jats:italic>r<\/jats:italic>\u2009=\u20090.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.02; <jats:italic>r<\/jats:italic>\u2009=\u20090.5, <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Children with UC had significantly lower ejection fraction and impaired left ventricular systolic function compared to the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) assessed by 3D STE, yet this observation was not reached by the conventional method (<jats:italic>P<\/jats:italic>\u2009=\u20090.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with UC, 3D STE could detect subclinical left ventricular systolic dysfunction that conventional echocardiography could not. AMC and LMR showed no significant difference between children with UC and controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16681","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T16:04:55Z","timestamp":1728144295000},"page":"803-808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subclinical left ventricular dysfunction and laboratory predictor of activity in children with ulcerative colitis: A single\u2010centre study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7379-6895","authenticated-orcid":false,"given":"Ahmed Said","family":"Behairy","sequence":"first","affiliation":[{"name":"Pediatrics Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehan","family":"Hussein","sequence":"additional","affiliation":[{"name":"Pediatrics Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Afifi","sequence":"additional","affiliation":[{"name":"Pediatrics Department Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Michel","sequence":"additional","affiliation":[{"name":"Pediatrics Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amera M","family":"Hasnoon","sequence":"additional","affiliation":[{"name":"Pediatrics Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.028"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2014.202"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.042"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61963-2"},{"key":"e_1_2_9_9_1","first-page":"2540","article-title":"Cardio vascular disease associated with ulcerative colitis","volume":"57","author":"Iizuka B","year":"1999","journal-title":"Nihon Rinsho"},{"key":"e_1_2_9_10_1","first-page":"243","article-title":"Pericarditis associated with longstanding mesalazine administration in a patient","volume":"68","author":"Vayre F","year":"1999","journal-title":"Int. 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