{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:32:32Z","timestamp":1783110752511,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the validity of WINROP use in multi\u2010ethnic population in a tertiary centre in Singapore.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Birth weight, gestational age, and weekly weight measurements of four hundred two preterm infants (&lt;32 weeks gestation) born between year 2011 and 2019 were entered into WINROP algorithm. Based on their weekly weight gain, WINROP algorithm would signal an alarm if the infant is at risk for type 1 ROP requiring treatment. The WINROP result is then compared with the ophthalmological findings. All the infants were screened  based on the hospital ROP screening protocol. The negative predictive value, positive predictive value, sensitivity and specificity were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all the infants enrolled, 31 infants developed type 1 ROP. WINROP successfully signalled 23 out of 31 correctly. The calculated sensitivity was 74.2 % and specificity was 48.0 %. The positive predictive value was 10.6% and negative predictive value was 95.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed that when WINROP is applied to our multi\u2010ethnic population, it has a moderate sensitivity of 74.2% and a high predictive negative value of 95.7%. We would not recommend it to be used a solitary screening method but it can be used to better risk stratify preterm infants at risk of type 1 ROP, particularly in resource limited settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16699","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T09:35:38Z","timestamp":1729157738000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of <scp>WINROP<\/scp> to predict severe retinopathy of prematurity in a multi\u2010ethnic cohort in <scp>Singapore<\/scp>"],"prefix":"10.1111","volume":"61","author":[{"given":"Kok Wooi","family":"Teoh","sequence":"first","affiliation":[{"name":"Singapore General Hospital Neonatal &amp; Developmental Medicine, Singapore Health Services (SingHealth) Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2442-0109","authenticated-orcid":false,"given":"Sudarshan","family":"Seshasai","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Duke Nus Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Grace Sy","family":"Tan","sequence":"additional","affiliation":[{"name":"Singapore General Hospital Neonatal &amp; Developmental Medicine  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Yan","family":"Ng","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha Atul","family":"Shah","sequence":"additional","affiliation":[{"name":"Singapore General Hospital Neonatal &amp; Developmental Medicine  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-4402","authenticated-orcid":false,"given":"Alvin Jia Hao","family":"Ngeow","sequence":"additional","affiliation":[{"name":"Singapore General Hospital Neonatal &amp; Developmental Medicine  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2510"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.205"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2017.05.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-1094-7"},{"key":"e_1_2_7_6_1","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized trial","volume":"102","author":"Good WV","year":"2004","journal-title":"Trans. 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