{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T05:06:23Z","timestamp":1736226383161,"version":"3.32.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Continuous monitoring of blood culture (BC) systems allows rapid detection of microbial growth. We aimed to determine differences in time to positivity (TTP) in BACTEC BC between organisms and whether a 36\u2010h period was sufficient to detect all relevant pathogenic bacteria for children admitted to a tertiary care paediatric hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective audit of positive aerobic (AE) and anaerobic (AN) BC from paediatric inpatients with available TTP from 1 August 2016 to 2 January 2019. First positive BC per bacteraemia episode was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 649\u2009BC were positive, of which 480 first positive BC were analysed: 246 AE (51.3%) only, 216 paired (45%) (108 AE and 108 AN) and 18 AN (3.8%) only. There were 372 episodes of bacteraemia in 340 patients. Median age was 19\u2009months (interquartile range (IQR): 1.25\u201360). Median TTP for AE and AN cultures was 13.20 (IQR: 9.84\u201318.48) and 13.92\u2009h (IQR: 10.32\u201317.04), respectively. Organisms were GNR 49.7%, GPC 29.6%, contaminants 14.5%, mixed 3.0%, other 2.4% and yeast 0.8%. <jats:italic>Streptococcus agalactiae<\/jats:italic> had the fastest median TTP in AE and AN cultures, followed by <jats:italic>Escherichia coli<\/jats:italic> (AE 8.88 vs. 10.20\u2009h). For paired AE and AN cultures, TTP was faster for AE versus AN cultures (13.36 vs. 14.52\u2009h, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). A 36\u2010h cut\u2010off time captured 97.7% AE BC and 99.1% AN BC with pathogens, and 86.5% AE BC and 91.7% AN BC with contaminants, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GNR were the commonest pathogens in paediatric BC and faster growth was detected in AE versus AN cultures. By 36\u2009h, &gt;97.7% of BC were positive for pathogens versus 86.5% for contaminants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16707","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T10:39:06Z","timestamp":1729679946000},"page":"39-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to positivity of blood cultures in paediatric patients"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9024-2529","authenticated-orcid":false,"given":"Catrin Kar Yee","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Paediatric Medicine KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie Woon Hui","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Service KK Women's and Children's Hospital  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Fu","family":"Yung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Service KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Maiwald","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine KK Women's and Children's Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-3324","authenticated-orcid":false,"given":"Chia Yin","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Service KK Women's and Children's Hospital  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