{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:09:03Z","timestamp":1789236543550,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2022QN053"],"award-info":[{"award-number":["2022QN053"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>This study sought to assess the clinical efficacy of honey suppositories in managing functional constipation in pre\u2010school children, with a focus on those exhibiting Yin deficiency and intestinal dryness according to traditional Chinese medicine principles. The investigation aimed to determine whether honey suppositories could serve as a safer and more efficacious alternative to standard treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled trial was conducted involving pre\u2010school children diagnosed with functional constipation. They were allocated to either a control group or a treatment group. While both groups received standard care, the treatment group also received honey suppositories. The efficacy of the treatment was evaluated based on the \u2018Guiding Principles for Clinical Research of New Chinese Medicines\u2019, and statistical analysis was performed using SPSS 25.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following treatment, the treatment group demonstrated significantly lower constipation scoring system scores and higher bowel movement frequencies compared with the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The clinical efficacy of the treatment group was notably superior, with a higher rate of complete recovery and effectiveness observed (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Additionally, no significant differences in baseline characteristics were found between the groups, confirming the comparability of the study cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Honey suppositories offer a promising therapeutic intervention for paediatric functional constipation, with significant clinical benefits over standard care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16722","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T04:48:08Z","timestamp":1731646088000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of honey suppositories in treating paediatric functional constipation: A comparative study"],"prefix":"10.1111","volume":"61","author":[{"given":"Guili","family":"Yu","sequence":"first","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinglian","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5908-2432","authenticated-orcid":false,"given":"Hui","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of traditional Chinese medicine Pujiang Community Health Service Center  Shanghai China"},{"name":"Longhua Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2020.1708718"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.815156"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-38068-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000266"},{"key":"e_1_2_8_6_1","first-page":"S55","article-title":"Long\u2010term follow\u2010up and course of life in children with constipation","volume":"53","author":"Bongers ME","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"e_1_2_8_7_1","first-page":"469","article-title":"Constipation in children and adolescents: Evaluation and treatment","volume":"105","author":"Mulhem E","year":"2022","journal-title":"Am. Fam. Physician"},{"key":"e_1_2_8_8_1","volume-title":"Rome IV: Functional Gastrointestinal Disorders\/Disorders of Gut\u2010Brain Interaction","author":"Drossman DA","year":"2016"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02056950"},{"key":"e_1_2_8_10_1","volume-title":"Ministry of Health of the People's Republic of China. 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