{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:32:10Z","timestamp":1783488730870,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the long\u2010term quality of life and surgical outcome of female patients with congenital adrenal hyperplasia (CAH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Questionnaires for health\u2010related quality of life (HRQoL) outcome (WHO\u20105, SF\u201036), lower urinary tract symptoms (ICIQ\u2010FLUTS) and sexual outcome (ICIQ\u2010FLUTSsex) were administered to adult CAH patients. Paediatric CAH patients and their parents were invited to complete WHO\u20105, PedsQL\u20104.0\u2010SF15\u2010Generic Core Scales and ICIQ\u2010CLUTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six (46%) adults and 7 (54%) children with 21\u2010hydroxylase\u2010deficiency (age ranged from 8\u2009years to 53\u2009years) were recruited. Eleven (85%) had undergone a feminising genitoplasty. In the adult group, no statistically significant difference was identified in the HRQoL and ICIQ\u2010FLUTS scores. Mean overall score of ICIQ\u2010FLUTSsex was lower but not significantly in adult patients compared to controls (7.3\u2009\u00b1\u20092.9 vs. 2.9\u2009\u00b1\u20093.4, <jats:italic>P<\/jats:italic>\u2009=\u20090.06). A statistically significant negative correlation (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.98, <jats:italic>P\u2009=<\/jats:italic>\u20090.02) was found between age at first operation and role limitations due to emotional problems in SF\u201036. No statistically significant difference was identified in the self\u2010reported HRQoL and ICIQ\u2010CLUTS scores in the paediatric group compared to controls. However, parent's report showed a statistically significant difference in school functioning (73.8\u2009\u00b1\u200918.9 vs. 91.2\u2009\u00b1\u200918.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and emotional functioning (80.3\u2009\u00b1\u200915.9 vs. 94.7\u2009\u00b1\u200912.7, <jats:italic>P<\/jats:italic>\u2009=\u20090.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data did not show an impaired HRQoL nor long\u2010term lower urinary tract symptoms in CAH patients' self\u2010reports. Healthcare team should pay more attention to adult patient's sexual function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16724","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:13:42Z","timestamp":1732320822000},"page":"153-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010term quality of life and surgical outcome of female congenital adrenal hyperplasia patients"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0923-5258","authenticated-orcid":false,"given":"Ling","family":"Leung","sequence":"first","affiliation":[{"name":"Department of Surgery School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candace","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Li","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy Hau Yee","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-503X","authenticated-orcid":false,"given":"Kenneth Kak Yuen","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital  Pokfulam Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01865"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70138-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.11.008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000435855"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0769-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2016.10.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2018.01.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.11.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.872436"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.12.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200108000-00006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20546"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.05.011"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00706652"},{"key":"e_1_2_11_16_1","first-page":"741","article-title":"Psychological adjustment in children and adults with congenital adrenal hyperplasia","volume":"144","author":"Berenbaum SA","year":"2004","journal-title":"J. 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