{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T14:10:11Z","timestamp":1758550211751,"version":"3.44.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["19\/367"],"award-info":[{"award-number":["19\/367"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to determine the degree of agreement between clinical and laboratory methods for diagnosing scabies in school\u2010aged children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical information and samples were collected from children aged 7\u2009months to 14\u2009years attending educational institutions in Auckland, New Zealand. Two methods determined scabies status: the International Alliance for the Control of Scabies clinical criteria (IACS) and quantitative polymerase chain reaction (qPCR). Sensitivity and specificity of each method, as the reference or index standard, were estimated and agreement was determined using Cohen's kappa statistic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen of 145 children were positive based on IACS criteria and 15 of 64 with a suspicious skin lesion returned a positive qPCR test. IACS sensitivity and specificity were 66.7% (95% confidence interval (CI): 39.9\u201393.3) and 94% (95% CI: 89.9\u201398.0), respectively (with qPCR as the reference). For qPCR, sensitivity and specificity were 50% (95% CI: 25.5\u201374.5) and 96.9% (95% CI: 94.0\u2013100.0), respectively (with IACS as the reference). The kappa value was 0.53.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Agreement between clinical and laboratory methods in the identification of scabies diagnosis was moderate. Both methods had low sensitivity but high specificity. Scabies diagnosis might be improved, thereby enhancing control measures, by relaxing the IACS criteria (as some IACS\u2010negative participants returned positive qPCR tests, indicating mite DNA was present) and conversely supplementing clinical assessment with qPCR testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.16738","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:23:56Z","timestamp":1733725436000},"page":"216-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Agreement between clinical criteria and quantitative polymerase chain reaction for diagnosing scabies in Auckland children"],"prefix":"10.1111","volume":"61","author":[{"given":"Tarun","family":"Nambiar","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanskruti","family":"Zaveri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Thornley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Selak","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7550-9096","authenticated-orcid":false,"given":"Gerhard","family":"Sundborn","sequence":"additional","affiliation":[{"name":"Department of Pacific Health, Faculty of Medical and Health Sciences The University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cielo","family":"Pasay","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute (ADF MIDI) QIMR Berghofer Medical Research Institute Herston  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur J","family":"Morris","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Laboratory, LabPLUS Auckland City Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-021-00348-6"},{"key":"e_1_2_8_3_1","first-page":"695","article-title":"Scabies: Epidemiology, diagnosis, and treatment","volume":"118","author":"Sunderk\u00f6tter C","year":"2021","journal-title":"Dtsch. 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