{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T06:10:11Z","timestamp":1746511811592,"version":"3.40.4"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Infantile tremor syndrome (ITS), or neurocutaneous infantile vitamin B12 deficiency syndrome (NIBS), is characterised by tremors, developmental delay, anaemia and skin hyperpigmentation. This study aimed to assess the body composition and serum lipids in children with ITS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children under 2\u2009years of age with a clinical diagnosis of ITS were enrolled. Dietary history, developmental milestones and anthropometric data were recorded, along with blood tests for B12, homocysteine, lipid profile and blood counts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 50 children screened, 31 with a median age of 13\u2009months were included. Most (80.6%) were from lower socio\u2010economic backgrounds. Limb tremors were observed in 51.6%, and all but one child had a developmental quotient (DQ) below 70, indicating significant developmental delays. Microcephaly was present in 35.4%, and moderate to severe anaemia was nearly universal. Growth parameters, including fat mass and fat\u2010free mass, were significantly lower in children with ITS compared to controls. Lipid profiles revealed consistently high triglycerides, low HDL and elevated LDL in most age groups, suggesting a pro\u2010atherogenic metabolic state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe Infantile vitamin B12 deficiency significantly impairs head growth, overall development and body composition, with potential long\u2010term cardiovascular risks due to abnormal lipid profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70000","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T04:38:42Z","timestamp":1739335122000},"page":"729-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Study of Body Composition in Children Suffering From Infantile Vitamin B12 Deficiency"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-5920","authenticated-orcid":false,"given":"Viresh","family":"Vohra","sequence":"first","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-0584","authenticated-orcid":false,"given":"Harvinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savita Verma","family":"Attri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhavneet","family":"Bharati","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivan","family":"Kesavan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveen","family":"Sankhyan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Advanced Pediatrics 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