{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:40:30Z","timestamp":1787060430873,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Paediatrics Child Health"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The variation in the clinical severity of viral infections remains a matter of scientific debate. Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) and Influenza A virus (IAV) are both RNA viruses, exhibiting a range of clinical presentations, ranging from asymptomatic cases to fatalities, influenced by both viral and host factors. A descriptive real\u2010life study was conducted, aiming to compare the clinical manifestations of recent COVID\u201019 with those of IAV infection in the same group of non\u2010hospitalised, unvaccinated children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method<\/jats:title>\n                    <jats:p>Between September 2021 and February 2023, we evaluated 115 individuals (male 48.7%, mean age 101.8\u2009\u00b1\u200950.8\u2009months) who had not received vaccination for both SARS\u2010CoV\u20102 and the quadrivalent influenza vaccine and were documented to be infected with both viruses within a 12\u2010month time interval. The visual analogue scale (VAS\u20105) was used to assess parents'\/patients' evaluation comparing the two infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In cases of IAV infection, a significantly higher prevalence of prolonged high fever, upper and lower respiratory symptoms, and secondary infections was observed. The majority (74.8%) of patients and\/or parents assessed IAV as a more severe clinical syndrome compared with SARS\u2010CoV\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The clinical burden of IAV was found to be greater than that of SARS\u2010CoV\u20102 infection in the same unvaccinated children. This variation in clinical severity may provide a reference for effective vaccination policies; however, underlying mechanisms that could explain this difference require further evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jpc.70014","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:35:05Z","timestamp":1739320505000},"page":"734-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Clinical Burden of\n                    <scp>SARS<\/scp>\n                    \u2010\n                    <scp>CoV<\/scp>\n                    \u20102 Compared to Influenza A in the Same Cohort of Paediatric Outpatients; Increased Influenza Severity and Potential Insights"],"prefix":"10.1111","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-664X","authenticated-orcid":false,"given":"Papadopoulou","family":"Athina","sequence":"first","affiliation":[{"name":"Pediatric Unit, KAT General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lampidi","family":"Stavroula","sequence":"additional","affiliation":[{"name":"Pediatric Unit, KAT General Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mermiri T.","family":"Despoina Zoe","sequence":"additional","affiliation":[{"name":"Pediatric Department Pentelis Children Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostaridou","family":"Stavroula","sequence":"additional","affiliation":[{"name":"Pediatric Department Pentelis Children Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanariou G.","family":"Maria","sequence":"additional","affiliation":[{"name":"Pediatric Immunology Unit, IASO Children's Hospital  Athens Greece"},{"name":"Department of Immunology\u2010Histocompatibility Agia Sophia Children Hospital Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151080"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2016.1227701"},{"key":"e_1_2_8_4_1","unstructured":"The United Nations Children's Fund (UNICEF) \u201cCOVID\u201019 Confirmed Cases and Deaths 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