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Careful assessment of children with prolonged fever without an obvious or identified source requires detailed history and examination with consideration of infections unique to the specific geographical region and individual exposure risks. Previous recommendations for diagnostic work\u2010up have provided valuable insights, but none have been tailored to the Australian inpatient setting. Recognising this gap, a diagnostic approach for infections specifically designed for the Australian child admitted to hospital with prolonged fever (\u200938.0\u00b0C) exceeding 7\u2009days is provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Level of Evidence<\/jats:title><jats:p>National Health and Medical Research Council Level V.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jpc.70027","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:04:32Z","timestamp":1741932272000},"page":"532-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged Fever in Children: An Inpatient Diagnostic Framework for Infections in Australia"],"prefix":"10.1111","volume":"61","author":[{"given":"Heshani","family":"Rupasinghe","sequence":"first","affiliation":[{"name":"Paediatric Department Gold Coast University Hospital  Southport Australia"},{"name":"Communicable Disease Control Public Health Unit, Gold Coast Hospital and Health Service  Southport Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Nourse","sequence":"additional","affiliation":[{"name":"Infection Management and Prevention Service, the Queensland Children's Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Robson","sequence":"additional","affiliation":[{"name":"Microbiology and Molecular Pathology Sullivan Nicolaides Pathology  Bowen Hills Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-7768","authenticated-orcid":false,"given":"Angela","family":"Berkhout","sequence":"additional","affiliation":[{"name":"Paediatric Department Gold Coast University Hospital  Southport Australia"},{"name":"Infection Management and Prevention Service, the Queensland Children's Hospital  Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196102000-00001"},{"issue":"4","key":"e_1_2_7_3_1","first-page":"544","article-title":"Prolonged Fever of Unknown Origin in Children","volume":"124","author":"McClung H. 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